儿童胃肠道功能障碍生物学标志物  

Biomarkers of gastrointestinal dysfunction in children

作　　者：殷凡 宁铂涛[1] Yin Fan;Ning Botao(Department of Pediatric Intensive Care Unit,Shanghai Children′s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心重症医学科,200127

出　　处：《中国小儿急救医学》2022年第12期951-956,共6页Chinese Pediatric Emergency Medicine

基　　金：上海市卫生计生委重要薄弱学科-儿科学(2016ZB0104)。

摘　　要：由于胃肠道屏障功能的不完善,儿童相较于成人更易发生胃肠道功能障碍。相关生物学标志物的临床应用有助于提高儿童胃肠道功能障碍的早期诊疗水平。通过对近年来相关文献的梳理,本文探究了炎症指标、肠道上皮屏障损害标志物、免疫学标志物、肠道菌群与胃肠道功能障碍的关系,总结了相关标志物研究中面临的主要问题和解决方法,以期有助于后续研究中相关生物学标志物的筛选、验证和临床应用。Due to incomplete function of gastrointestinal barrier,children are more likely to develop gastrointestinal dysfunction.The clinical application of related biomarkers helps early diagnosis and treatment of gastrointestinal dysfunction in children.By sorting out the studies in recent years,we explored the relationship between inflammatory indicators,intestinal epithelial barrier damage biomarkers,immunological biomarkers,gut microbiome and gastrointestinal dysfunction,and summarized the main problems and solutions faced in the research,which may help the screening,identification and clinical application of relevant biomarkers in subsequent research.

关 键 词：儿童 胃肠道功能障碍 炎症标志物 肠道上皮屏障损害标志物 免疫学标志物 肠道菌群 

分 类 号：R725.7[医药卫生—儿科]