2型糖尿病与原发性开角型青光眼的关系  

Correlation between type 2 diabetes mellitus and primary open angle glaucoma

作　　者：刘金龙 胡海坚 张旭[1] Liu Jinlong;Hu Haijian;Zhang Xu(Affiliated Eye Hospital of Nanchang University,Jiangxi Research Institute of Ophthalmology and Visual Science,Jiangxi Clinical Research Center of Ophthalmic Disease,Jiangxi Branch of National Clinical Research Center for Ocular Diseases,Nanchang 330006,China)

机构地区：[1]南昌大学附属眼科医院、江西省眼科学与视觉科学研究所、江西省眼科疾病临床医学研究中心、国家眼耳鼻喉疾病临床医学研究中心江西省分中心,330006

出　　处：《国际眼科纵览》2022年第5期471-477,共7页International Review of Ophthalmology

基　　金：国家自然科学基金(81860170);江西省自然科学基金(20181ACG70010)。

摘　　要：青光眼与糖尿病眼病都是世界范围内严重威胁视力的疾病,2型糖尿病(type 2 diabetes mellitus,T2DM)患者可伴有视神经退行性改变及视网膜神经节细胞凋亡,这些表现与原发性开角型青光眼(primary open angle glaucoma,POAG)的视神经损害相似。T2DM患者表现的高眼压、血管病变及视网膜变薄等危险因素可能会加重POAG的进展,而治疗糖尿病的药物如二甲双胍可能对POAG具有保护作用。进一步探究T2DM和POAG的关系,可能有助于降低T2DM患者的视力损害风险及发现POAG新的治疗方法。Glaucoma and diabetic eye disease are both serious vision-threatening diseases worldwide.Patients with type 2 diabetes mellitus(T2DM)may be accompanied by optic nerve degeneration and retinal ganglion cells(RGC)apoptosis,which are similar to the optic nerve damage of primary open-angle glaucoma(POAG).Risk factors such as high intraocular pressure,vasculopathy and retinal thinning in patients with T2DM may aggravate the progression of POAG,while pharmacological treatments for diabetes such as metforminmay have a protective effect on POAG.Further exploration of the relationship between T2DM and POAG may help reduce the risk of visual impairment in patients with T2DM and discover new treatment target for POAG.

关 键 词：原发性开角型青光眼 2型糖尿病 视神经 血流调节 

分 类 号：R587.2[医药卫生—内分泌] R775[医药卫生—内科学]