细胞因子对噬血细胞综合征影响的研究进展  

Research progress on the effect of cytokines on hemophagocytic syndrome

作　　者：王敏(综述) 王娅婕[1,2] 杨同华(审校) WANG Min;WANG Yajie;YANG Tonghua(School of Medicine,Kunming University of Science and Technology,Kunming,Yunnan 650500,China;Department of Hematology,First People’s Hospital of Yunnan Province,Kunming,Yunnan 650032,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]云南省第一人民医院血液科,昆明650032

出　　处：《重庆医学》2023年第3期456-460,共5页Chongqing medicine

基　　金：国家自然科学基金项目(82070173);云南省临床医学中心开放课题(2019LCZXKF-XY11,2021LCZXXF-XY09)。

摘　　要：噬血细胞综合征(HLH)是体内炎症细胞因子过度分泌造成身体多器官多组织损伤的一系列综合征。临床上选择的治疗主要参考HLH-1994与HLH-2004方案,但患者的生存情况仍不理想。在HLH病程中,不同水平的细胞因子有助于早期诊断及预后判断。目前已经证实,白细胞介素(IL)-6、IL-10、IL-18、干扰素-γ在HLH患者中过量表达,且提示预后不良。根据细胞因子在HLH发生、发展中的作用,研发具有针对性的治疗手段,这在改善患者预后、减少并发症等方面具有巨大潜力。该文主要就细胞因子类生物标志在HLH发生、发展、预后中的研究进展进行综述。Hemophagocytic syndrome(HLH) is a series of syndromes that damage multiple organs and tissues caused by excessive secretion of inflammatory factors in the body.The clinically selected treatment mainly refers to HLH-1994 and HLH-2004,but the survival of patients is still not ideal.Studies have shown that different levels of cytokines in the course of HLH are helpful for early diagnosis and prognosis.It has been confirmed that IL-6,IL-10,IL-18,and IFN-γ are overexpressed in HLH patients and indicate poor prognosis.Targeted treatments based on the role of cytokines in the occurrence and development of HLH have great potential in improving patient prognosis and reducing complications.This article reviewed the research progress of cytokine biomarkers in the occurrence, development, and prognosis of HLH.

关 键 词：噬血细胞综合征 细胞因子 治疗 预后 危险因素 

分 类 号：R599[医药卫生—内科学]