基于多模态超声的原发性甲状腺淋巴瘤诊断模型构建分析  

Construction and analysis of diagnostic model of primary thyroid lymphoma based on multimodal ultrasound

作　　者：刘雪平 周余旺 刘庆华[1] 邱俊芬 LIU Xueping;ZHOU Yuwang;LIU Qinghua;QIU Junfen(Department of Ultrasound,Quzhou Hospital Affiliated to Wenzhou Medical University(Quzhou People's Hospital),Quzhou324000,Zhejiang,China)

机构地区：[1]温州医科大学附属衢州医院(衢州市人民医院)超声科,浙江衢州324000

出　　处：《中国现代医生》2023年第2期75-80,共6页China Modern Doctor

摘　　要：目的 构建基于多模态超声的原发性甲状腺淋巴瘤诊断预测模型,并分析其预测效能。方法 回顾性选取2015年1月至2020年3月衢州市人民医院收治的30例原发性甲状腺淋巴瘤(primary thyroid lymphoma,PTL)患者(PTL组)和30例桥本甲状腺炎(hashimoto thyroiditis,NHT)患者(NHT组)为研究对象,所有患者均接受组织病理学检查及多模态超声检查,评估PTL和NHT结节在多模态超声检查上的成像特征参数差异,对有价值的参数进行多因素Logistic回归分析,绘制受试者操作特征(receiver operating characteristic,ROC)曲线,分析预测模型的诊断效能。结果 多模态超声检查显示,PTL组和NHT组成像特征参数比较,结节最大直径、达峰时间(time to peak,TTP)比、时间-强度曲线(time-signal intensity curve,TIC)面积比、血管分布、峰值强度(peak intensity,PI)比及向心增强型,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示结节最大直径、TTP比、TIC面积比、血管分布、PI比是PTL的诊断因子。ROC曲线显示诊断模型曲线下面积为0.940,特异性为93.43%,敏感度为92.74%。结论 在原发性甲状腺淋巴瘤诊断中,通过多模态超声检查患者甲状腺结节最大直径、TTP比、TIC面积比、血管分布、PI比建立的预测模型可用于鉴别诊断PTL和NHT。Objective To construct a multimodal ultrasound-based diagnostic and predictive model for primary thyroid lymphoma and analyze its predictive performance. Methods Thirty patients with primary thyroid lymphoma(PTL)(PTL group)and thirty patients with hashimoto thyroiditis(NHT)(NHT group) admitted to Quzhou People’s Hospital from January 2015 to March 2020 were retrospectively selected as the research subjects. All patients underwent histopathological examination and multimodal ultrasonography to evaluated the differences in imaging characteristic parameters of PTL and NHT nodules on multimodal ultrasonography. Multivariate Logistic regression analysis was performed on valuable parameters, and receiver operating characteristic(ROC) curve was drawn to analyze the diagnostic performance of the predictive model. Results Multimodal ultrasonography showed that there were statistically signficant differences between the PTL and NHT groups in the imaging characteristic parameters diameter, time to peak(TTP) ratio, time-signal intensity curve(TIC) area ratio, blood vessel distribution, peak intensity(PI) ratio and centripetal enhancement(P<0.05). Multivariate Logistic regression analysis showed that nodule maximum diameter, TTP ratio and TIC area ratio, vascular distribution, and PI ratio were the diagnostic factors of PTL. The ROC curve showed that the diagnostic model area under the curve was 0.940, the specificity was 93.43%, and the sensitivity was 92.74%. Conclusion In the diagnosis of primary thyroid lymphoma, the prediction model established by multimodal ultrasound examination of the maximum diameter of the patient’s thyroid nodule, TTP ratio, TIC area ratio, blood vessel distribution, PI ratio can be used to differentially diagnose PTL and NHT.

关 键 词：多模态超声 原发性甲状腺淋巴瘤 桥本甲状腺炎 诊断预测模型 

分 类 号：R445.1[医药卫生—影像医学与核医学]