高强度间歇训练对2型糖尿病患者血糖控制及胰腺β细胞功能的影响  

Effects of high-intensity interval training on glycemia and the pancreaticβ-cell functioning of persons with type 2 diabetes

作　　者：张王利[1] 祖翰卿 王晨宇[2] 曹乃鑫 Zhang Wangli;Zu Hanqing;Wang Chenyu;Cao Naixin(School of Sports and Health,Zhengzhou Shengda University of Economics Business&Management,Zhengzhou 451191,China;Research Center of Physical Health and Culture,Zhengzhou University of Aeronautics,Zhengzhou 450015,China)

机构地区：[1]郑州升达经贸管理学院体育学院,郑州451191 [2]郑州航空工业管理学院体育健康与文化研究中心,郑州450015

出　　处：《中华物理医学与康复杂志》2022年第12期1084-1089,共6页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的探讨8周高强度间歇训练(HIIT)对2型糖尿病患者血糖控制及胰腺β细胞功能的影响,为优化糖尿病运动干预方案提供参考。方法采用随机数字表法将60例无规律运动习惯的2型糖尿病患者分为运动组及对照组,每组30例。2组患者均维持日常生活习惯不变,运动组患者同时采用功率车测功仪进行每周3次、共8周HIIT干预。于干预前、干预8周后采用2 h口服葡萄糖耐量试验(OGTT)检测患者血糖控制及胰腺β细胞功能,采用双能量X射线吸收法检测身体成分变化。结果与干预前比较,干预后运动组空腹血糖(FPG)、平均血糖、糖化血红蛋白(HbA_(1c))、OGTT 2 h末血糖含量、血糖曲线下面积(AUC)均显著减少(P<0.05),稳态模型胰岛素抵抗指数(HOMA-IR)明显降低(P<0.05),稳态模型评估β细胞功能指数(HOMA-%β)及处置指数(DI)均明显升高(P<0.05),腰围和腹部脂肪含量均显著降低(P<0.05),对照组干预后上述各项指标参数均无显著变化(P>0.05)。干预期间运动组有1例患者失访,其训练计划完成率为98.4%,且运动期间及运动后均无明显不良反应事件发生。结论8周HIIT干预能改善2型糖尿病患者血糖控制、胰腺β细胞功能并降低腹部脂肪含量,可作为2型糖尿病患者运动康复干预的有效手段。Objective To explore any effect of 8 weeks of high-intensity interval training(HIIT)on glycemia and pancreaticβ-cell function among persons with type 2 diabetes to provide data for optimizing their exercise protocol.Methods Sixty patients with type 2 diabetes and without a habit of regular exercise were randomly divided into an exercise group(n=30)and a control group(n=30).Both groups maintained their daily living habits,except that the exercise group practiced HIIT on a power vehicle ergometer 3 times a week for 8 weeks.Before and after the intervention,the 2-hour oral glucose tolerance test(OGTT)was conducted to evaluate glycemia and pancreatic β-cell function.Body composition was also detected using dual-energy X-ray absorptiometry.Results After the intervention a significant decrease was observed in the fasting blood glucose,mean blood glucose,glycosylated hemoglobin,blood glucose levels at the end of a 2h OGTT,blood glucose area under the curve and homeostatic model assessment of insulin resistance,as well as waist circumference and abdominal fat content of the exercise group.And there was a significant increase in the homeostatic model assessment of pancreaticβ-cell function and disposition index among the exercise group.In the control group no significant differences were observed.Conclusion Eight weeks of HIIT can improve glycemia and pancreaticβ-cell function and reduce abdominal fat among persons with type 2 diabetes.It can be used as an effective rehabilitation protocol.

关 键 词：高强度间歇训练 2型糖尿病 血糖控制 胰腺β细胞功能 身体成分 

分 类 号：R587.1[医药卫生—内分泌]