Dectin-1在宿主抗隐球菌感染的机制与研究进展  

Mechanism and research progress of Dectin-1 against cryptococcal infection in host

作　　者：于柯瑶 张克明 黄越 廖万清 潘炜华 Yu Keyao;Zhang Keming;Huang Yue;LiaoWanqing;PanWeihua(Department of Dermatology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China)

机构地区：[1]海军军医大学第二附属医院皮肤科,上海200003

出　　处：《广西医科大学学报》2023年第1期1-5,共5页Journal of Guangxi Medical University

基　　金：中国工程院战略研究与咨询项目(No.2022-HZ-10-03)。

摘　　要：固有免疫在隐球菌感染中发挥着至关重要的作用,宿主建立对隐球菌有效免疫应答的第一步是通过固有免疫应答细胞表达的模式识别受体(PRR)识别隐球菌病原体相关分子模式(PAMP),进一步触发涉及许多蛋白质(脾酪氨酸激酶和胱天蛋白酶募集域蛋白9等)的细胞内信号级联反应。本篇综述中笔者总结了固有免疫应答细胞模式识别受体Dectin-1与隐球菌病原体相关分子模式的相互识别机制,并讨论了Dectin-1信号通路在宿主抗隐球菌感染免疫中的作用及其在隐球菌病药物和疫苗佐剂研发中的潜在应用。Innate immunity plays a crucial role in cryptococcal infection.The first step for the host to establish an effective immune response to cryptococcal infection is to recognize the cryptococcal pathogen-associated molecular patterns(PAMP)through pattern recognition receptors(PRR)expressed by innate immune response cells.Then intracellular signaling cascades are triggered involving many proteins(splenic tyrosine kinase and caspase recruitment domain-containg protein 9,etc.).In this review,we summarize the mutual recognition mechanism between the innate immune response cell pattern recognition receptor Dectin-1 and cryptococcal pathogen-associated molecular patterns,and discuss the role of Dectin-1 signaling pathway in host immunity against cryptococcal infection and its potential application in the development of cryptococcal drugs and vaccine adjuvants.

关 键 词：隐球菌 DECTIN-1 受体 天然免疫 抗原递呈细胞 

分 类 号：R519.4[医药卫生—内科学]