贵港市覃塘区2年内阳转的艾滋病新发感染病例生存状况分析  

Survival analysis of newly HIV/AIDS cases with seroconversion within 2 years in Qintang district, Guigang city

作　　者：徐月香[1] 洪雯 梁贤君 黄运轩[1] 覃春伟[1] 徐志良[1] 邓本本 叶力 Xu Yuexiang;Hong Wen;Liang Xianjun;Huang Yunxuan;Qin Chunwei;Xu Zhiliang;Deng Benben;Ye Li(Guigang Center for Disease Control and Prevention,Guigang 537100,China;Guangxi Key Laboratory of AIDS Prevention and Treatment,School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]贵港市疾病预防控制中心,贵港537100 [2]广西医科大学公共卫生学院广西艾滋病防治研究重点实验室,南宁530021

出　　处：《广西医科大学学报》2023年第1期13-19,共7页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.31970167);贵港市科学研究与技术开发计划项目-科技创新能力建设基金资助项目(No.1903004)。

摘　　要：目的:分析贵港市覃塘区经过2轮人类免疫缺陷病毒(HIV)大筛查后2年内阳转的艾滋病新发感染病例的生存状况及影响因素,为更好地开展艾滋病防治工作和提高患者生存率提供依据。方法:采用回顾性队列研究方法,分析贵港市覃塘区2013年1月至2017年6月新报告的且最近2年内有过阴性检测记录的艾滋病新发感染病例的死亡概率和生存率,分别计算治疗者和未治疗者的病死率。利用多因素Cox比例风险模型对患者生存的影响因素进行分析。结果:治疗者的病死率为1.8/100人年,未治疗者的病死率为39.6/100人年。总体患者在随访后的第1、第3、第5年的死亡概率和生存率分别为11.98%、6.54%、9.92%和88.02%、74.48%、63.33%。多因素分析结果显示,年龄≥50岁、未接受抗病毒治疗和首次CD4+T淋巴细胞≤200个/μL是患者生存的危险因素(均P<0.05)。结论:贵港市覃塘区2年内阳转的艾滋病新发感染病例生存率较低,有必要在人群中加强宣传、扩大检测范围;早发现、早诊断、早接受抗病毒治疗是降低病死率、延长生存寿命的有效措施。Objective: To analyze the survival status and influencing factors of newly HIV/AIDS cases with seroconversion within 2 years after two human immunodeficiency virus(HIV) screenings in Qintang district, Guigang city, so as to provide a basis for better HIV prevention and treatment and improve the survival rate of patients. Methods: A retrospective cohort study was conducted to analyze the mortality and survival rate of HIV/AIDS patients newly reported from Qintang District of Guigang City from January 2013 to June 2017 with negative test records in the last 2 years. The mortality rates of treated and untreated patients were calculated respectively. A retrospective cohort study was used to analyze the mortality and survival rate of newly reported new HIV infection cases who had a negative test record within the last 2 years in Qintang district, Guigang city from March2013 to June 2017, and to calculate the fatality rates of treated and untreated patients, respectively. The multivariate Cox proportional hazard model were used to analyze the influencing factors of patients’ survival by multivariate analysis. Results: The fatality rate of treated patients was 1.8/100 person-years, and the fatality rate of untreated patients was 39.6/100 person-years. The mortality and survival rates of the overall patients at the first, third and fifth year after follow-up were11.98%, 6.54%, 9.92%, and 88.02%, 74.48%, and63.33%, respectively. The results of multivariate analysis showed that age ≥ 50 years old, no antiviral treatment, and first CD4+T lymphocytes ≤ 200 cells/μL were independent risk factors for patients’ survival(all P<0.05). Conclusion: The survival rate of newly infected HIV/AIDS cases within 2 years in Qintang district of Guigang city is low. It is necessary to strengthen the propaganda and expand HIV screening in the population. In addition, early detection, early diagnosis and early antiretroviral are the effective measures to reduce the mortality rate and increase survival life expectancy.

关 键 词：阳转 HIV 新发感染 生存分析 

分 类 号：R512.91[医药卫生—内科学]