督灸联合西药治疗肾阳虚型轻中度抑郁症:随机对照试验  

Governor vessel moxibustion combined with western medication for mild to moderate depression with kidney-yang deficiency: a randomized controlled trial

作　　者：李旭豪 李金玲[1] 董甜甜 马欣 薛玺情 杨继国[1] LI Xu-hao;LI Jin-ling;Dong Tian-tian;MA Xin;XUE Xi-qing;YANG Ji-guo(School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM,Jinan 250355,China;External Treatment Center of TCM,Affiliated Hospital of Shandong University of TCM;Innovation Research Institute of TCM,Shandong University of TCM,Jinan 250355,China)

机构地区：[1]山东中医药大学针灸推拿学院,济南250355 [2]山东中医药大学附属医院中医外治中心 [3]山东中医药大学中医药创新研究院,济南250355

出　　处：《中国针灸》2023年第1期14-18,共5页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金面上项目:82174491。

摘　　要：目的:比较督灸联合盐酸氟西汀胶囊、单纯盐酸氟西汀胶囊与安慰灸联合盐酸氟西汀胶囊治疗肾阳虚型轻中度抑郁症的临床疗效。方法:将126例肾阳虚型轻中度抑郁症患者随机分为督灸组(42例,脱落2例)、西药组(42例,脱落1例)和安慰灸组(42例,脱落1例)。西药组予口服盐酸氟西汀胶囊(每次20mg,每日1次)。在西药组治疗基础上,督灸组于大椎至腰俞段行督灸治疗(每周1次);安慰灸组予安慰灸(每周1次)。3组均治疗8周。比较各组患者治疗前后汉密尔顿抑郁量表(HAMD-17)评分、Asberg氏抗抑郁剂副反应量表(SERS)评分及中医临床症状积分,并评定临床疗效。结果:与治疗前比较,3组患者治疗后HAMD-17评分、SERS评分、中医临床症状积分均降低(P<0.05);督灸组各评分降低幅度大于西药组和安慰灸组(P<0.05)。督灸组总有效率为92.5%(37/40),高于西药组的75.6%(31/41)和安慰灸组的80.5%(33/41,P<0.05)。结论:督灸联合盐酸氟西汀胶囊可改善肾阳虚型轻中度抑郁症患者抑郁程度,缓解临床症状,总体疗效优于单纯盐酸氟西汀胶囊,可在一定程度上减轻盐酸氟西汀胶囊的不良反应。Objective To compare the therapeutic efficacy of governor vessel moxibustion combined with fluoxetine hydrochloride capsule, simple fluoxetine hydrochloride capsule and placebo moxibustion combined with fluoxetine hydrochloride capsule for mild to moderate depression with kidney-yang deficiency. Methods A total of 126 patients with mild to moderate depression with kidney-yang deficiency were randomized into a governor vessel moxibustion group(42 cases, 2 cases dropped off), a western medication group(42 cases, 1 case dropped off) and a placebo moxibustion group(42 cases, 1 case dropped off).The western medication group was given fluoxetine hydrochloride capsule orally, 20 mg a time, once a day. On the basis of the treatment in the western medication group, governor vessel moxibustion was applied from Dazhui(GV 14) to Yaoshu(GV 2) in the governor vessel moxibustion group, once a week;placebo moxibustion was applied in the placebo moxibustion group, once a week. Treatment of 8 weeks was required in the 3 groups. Before and after treatment, the scores of Hamilton depression scale-17(HAMD-17), Asberg’s rating scale for side effects(SERS) and TCM clinical symptom were compared, and the clinical efficacy was evaluated. Results After treatment, the scores of HAMD-17, SERS and TCM clinical symptom were decreased compared before treatment in the 3 groups(P<0.05), the decrease ranges of above scores in the governor vessel moxibustion group were larger than those in the western medication group and the placebo moxibustion group(P<0.05). The total effective rate was 92.5%(37/40) in the governor vessel moxibustion group, which was higher than 75.6%(31/41) in the western medication group and 80.5%(33/41) in the placebo moxibustion group(P<0.05). Conclusion Governor vessel moxibustion combined with fluoxetine hydrochloride capsule can improve the degree of depression and relieve the clinical symptoms in mild to moderate depression patients with kidney-yang deficiency, the efficacy is superior to simple fluoxetine hydrochlorid

关 键 词：轻中度抑郁症 督灸 安慰灸 盐酸氟西汀胶囊 肾阳虚 汉密尔顿抑郁量表(HAMD-17)评分 Asberg氏抗抑郁剂副反应量表(SERS)评分 

分 类 号：R246.6[医药卫生—针灸推拿学]