血清NT-proBNP、H-FABP、VEGF-B对冠心病病情及心功能的预测价值  

Value of Serum NT-proBNP,H-FABP and VEGF-B in Predicting Coronary Heart Disease and Cardiac Function

作　　者：井晓 杨妙迎 JING Xiao;YANG Miao-ying(Department of Laboratory Medicine,Xi'an High-tech Hospital,Xi'an Shaanxi 710075)

机构地区：[1]西安高新医院检验科,陕西西安710075 [2]西安大兴医院检验科,陕西西安710082

出　　处：《医学临床研究》2023年第1期85-87,91,共4页Journal of Clinical Research

摘　　要：[目的]探讨N末端B型利钠肽原(NT-proBNP)、心型脂肪酸结合蛋白(H-FABP)、血管内皮生长因子-B(V EG F-B)预测冠心病病情及心功能的价值.[方法]选择两院收治的87例冠心病患者作为观察组,80例健康体检者作为对照组.比较观察组治疗前后及与对照组的NT-proBNP、H-FABP、VEGF-B水平,左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左室射血分数(LVEF)、心输出量(CO)、心脏指数(CI)的差异,并分析观察组患者治疗前后的美国纽约心脏病学会(NYHA)心功能分级变化.[结果]对照组的NT-proBNP、H-FABP、VEGF-B水平显著低于观察组治疗前及治疗后(P<0.05);观察组患者治疗后的NT-proBNP、H-FABP、VEGF-B水平显著低于治疗前(P<0.05).对照组的LVEDV、LVESV、LVEF水平显著高于观察组治疗前和治疗后(P<0.05);观察组治疗后的LVEDV、LVESV、LVEF水平显著高于治疗前(P<0.05);对照组的CO、CI显著高于观察组治疗前(P<0.05),观察组治疗后的CO显著高于治疗前(P<0.05).对照组与观察组治疗后的CO、CI水平比较,差异均无统计学意义(P>0.05).观察组患者治疗后的心功能级别显著高于治疗前(P<0.05).[结论]NT-proBNP、H-FABP、VEGF-B水平的变化可预测冠心病患者病情严重程度.【Objective】To study the effects of changes in NT-proBNP,H-FABP,and VEGF-B levels on cardiac function in patients with coronary heart disease.【Methods】Eighty-seven patients with coronary heart disease were selected as the observation group,and 80 healthy subjects were used as the control group.NT-proBNP,H-FABP,VEGF-B,left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),cardiac output,volume(CO)and cardiac index(CI)were measured before and after treatment in the observation group;And they were compared with the control group.The NYHA cardiac function grading before and after treatment in the observation group were analyzed.【Results】The levels of NT-proBNP,H-FABP,and VEGF-B in the control group were significantly lower than those in the observation group both before treatment and after treatment.The NT-proBNP,H-FABP and VEGF-B levels in the observation group after treatment were significantly lower than those before treatment(P<0.05).The LVEDV,LVESV,and LVEF levels in the control group were significantly higher than those before treatment and after treatment in the observation group.After treatment,LVEDV,LVESV,and LVEF levels of the observation group were significantly higher than those before treatment.The CO and CI of the control group were significantly higher than those of the observation group.The CO of the observation group after treatment was significantly higher than that before treatment(P<0.05).There were no significant differences in CO and CI between the control group and the observation group(P>0.05).The cardiac function of the observation group after treatment was significantly higher than that before treatment;And the difference was statistically significant(P<0.05).【Conclusion】Detection of changes in NT-proBNP,H-FABP,and VEGF-B levels can predict the severity of patients with coronary heart disease.

关 键 词：冠心病 利钠肽 脑/血液 脂肪酸结合蛋白质3/血液 血管内皮生长因子B/血液 心脏功能试验 

分 类 号：R541.4[医药卫生—心血管疾病]