狼疮性肾炎患者血浆中ADAMTS13水平与疾病活动度的相关性  

Relationship of Plasma ADAMTS13 Level with Disease Activity in Patients with Lupus Nephritis

作　　者：王小艳[1] 贺亚峰 WANG Xiao-yan;HE Ya-feng(Second Department of Internal Medicine,Armed Police Corps Hospital of Shaanxi,Xi'an Shaanxi 710086)

机构地区：[1]武警陕西总队医院内二科,陕西西安710086 [2]武警陕西总队医院门诊部,陕西西安710086

出　　处：《医学临床研究》2023年第1期88-91,共4页Journal of Clinical Research

摘　　要：【目的】探讨狼疮性肾炎(LN)患者血浆血管性血友病因子裂解蛋白酶(ADAMTS13)水平与疾病活动度的相关性。【方法】以本院2018年10月至2020年12月收治的LN患者100例为LN组,根据红斑狼疮疾病活动性指数(SLEDAI)将其分为基本无活动组、轻度活动组、中度活动组、重度活动组,另外选取同期健康体检者100例为对照组。收集各组临床资料及血生化指标,测定所有对象血浆中ADAMTS13、血管性血友病因子(VWF)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)表达水平。【结果】与对照组相比,LN组患者三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、尿酸水平显著升高(P<0.05),载脂蛋白A1(apoA-1)显著降低(P<0.05)。对照组及基本无活动组、轻度活动组、中度活动组、重度活动组LN患者红细胞、白细胞、血小板、血红蛋白、补体C3和C4、血浆中ADAMTS13水平依次降低,血浆中炎性因子IL-6、TNF-α及VWF、VWF/ADAMTS13水平依次升高,且各组比较差异均有统计学意义(P<0.05)。LN患者血浆中ADAMTS13水平与IL-6、TNF-α、VWF水平、SLEDAI呈显著负相关(r=-0.405、-0.464、-0.465、-0.925,均P<0.05)。【结论】ADAMTS13在LN患者血浆中呈低表达,其水平变化对于评估LN患者疾病活动度具有重要意义。【Objective】To investigate the relationship of ADAMTS13 level(von Willebrand factor lytic protease)with disease activity in patients with lupus nephritis(LN).【Methods】A total of 100 patients with LN admitted to our hospital from October 2018 to December 2020 were selected as the LN group.According to the systemic lupus erythematosus disease activity index(SLEDAI),patients were divided into the basically inactivity group,mild activity group,moderate activity group and severe activity group.While 100 healthy people in the same period were selected as the control group.Clinical data and blood biochemical indexes were collected.The plasma levels of ADAMTS13,von Willebrand factor(VWF),interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were determined.【Results】Compared with the control group,the levels of triacylglycerol(TG),low density lipoprotein(LDL-C)and uric acid in the systemic lupus erythematosus group were significantly higher(P<0.05),while apoA-1 were significantly lower(P<0.05).Compared to the control group,the levels of plasma ADAMTS13,red blood cells,white blood cells,platelets,hemoglobin,complement C3,C4,and plasma of LN patients in the basically inactive group,mildly active group,moderately active group,and severely active group decreased gradually;And plasma levels of inflammatory factors IL-6,TNF-α,VWF and VWF/ADAMTS13 increased in the order of the basically inactive group,mildly active group,moderately active group,and severely active group(P<0.05).The levels of plasma ADAMTS13 in patients with LN were negatively correlated with the levels of IL-6,TNF-α,VWF and SLEDAI(r=-0.405,-0.464,-0.465,-0.925,P<0.05).【Conclusion】The expression of ADAMTS13 in plasma is low in patients with LN,and the change of ADAMTS13 level is of great significance for the evaluation of disease activity in patients with LN.

关 键 词：狼疮肾炎 ADAMTS13蛋白质/血液 

分 类 号：R593.242[医药卫生—内科学]