Meta-analysis for the efficacy and safety of Hanchuan Zupa Granule in treating bronchial asthma  

作　　者：HAN Jing JIA Yan-kun HAN Ze-Llu ZHAO Rui-heng YIN Ze-tao LIN Jiang-tao 

机构地区：[1]Clinical Medical College(China-Japan Friendship Hospital),Beijing University of Chinese Medicine,Beijing 100029,China [2]Department of Respiratory and Critical Care Medicine,China-Japan Friendship Hospital,Beijing 100029,China

出　　处：《Journal of Hainan Medical University》2022年第16期30-39,共10页海南医学院学报（英文版）

基　　金：National Natural Science Foundation of China(NO.82170027)。

摘　　要：Objective:To systematically evaluate the clinical efficacy and safety of Hanchuan Zupa granule(HCZPG)in the treatment of bronchial asthma.Methods:The Cochrane Library,Pubmed,EMBASE,CNKI,CBM,VIP and Wanfang were searched up to June 2021.Randomized controlled trials,which assessed the effects of HCZPG in the treatment of bronchial asthma,were included in this review,and the references included in the selected studies were also tracked.The methodological quality of eligible studies were assessed by the Cochrane Collaboration’s tool.Data of the included studies were extracted independently by two authors and meta-analysis was conducted using RevMan5.3.Results:A total of 97 relevant literatures were retrieved,and 13 studies were finally included,involving 1189 patients.The aggregated meta-analysis results indicated that HCZPG improved total clinical efficacy[RR=1.18,95%CI(1.13,1.24),P<0.00001],FEV1(L)[WMD=0.48,95%CI(0.22,0.74),P=0.0003],FVC(L)[WMD=1.23,95%CI(0.5,1.96),P=0.001],FEV1/FVC(%)[WMD=7.37,95%CI(5.91,8.84),P<0.00001],PEF[SMD=1.19,95%CI(0.82,1.56),P<0.00001],IL-4[WMD=-12.13,95%CI(-16.36,-7.90),P<0.00001],IL-6[WMD=-29.55,95%CI(-40.71,-18.39),P<0.00001],TNF-α[SMD=-2.73,95%CI(-3.57,-1.88),P<0.00001],PaO2[WMD=8.97,95%CI(6.09,11.85),P<0.00001],but the risk of adverse events were not statistically significant between the two groups[RR=0.68,95%CI(0.39,1.18),P=0.17].Conclusion:HCZPG shows good clinical curative effects in treating bronchial asthma without increasing the incidence of adverse events.

关 键 词：Hanchuan Zupa granule ASTHMA RCTS Systematic review META-ANALYSIS 

分 类 号：R562.25[医药卫生—呼吸系统]