河南省新密市孕妇及新生儿巨细胞病毒感染流行特征分析  

Epidemiology of CMV Infection in Pregnant Women and Newborns in Xinmi, Henan Province, China

作　　者：李慧锋 黄悦 李红娟 郑凤仙 李彩红 朱孔鑫 黄兴成 胡潇文 苏迎盈[2] LI Huifeng;HUANG Yue;LI Hongjuan;ZHENG Fengxian;LI Caihong;ZHU Kongxin;HUANG Xingcheng;HU Xiaowen;SU Yingying(Xinmi Maternal and Child Health Hospital,Zhengzhou 452370,China;National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Collaborative Innovation Center of Biologic Products,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]新密市妇幼保健院,郑州452370 [2]厦门大学公共卫生学院,国家传染病诊断试剂与疫苗工程技术研究中心,分子疫苗学和分子诊断学国家重点实验室,医用生物制品省部共建协同创新中心,厦门361102

出　　处：《病毒学报》2023年第1期105-112,共8页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:81973058),题目:抗体阳性孕妇中巨细胞病毒垂直传播及相关不良临床结局危险因素研究。

摘　　要：本研究旨在分析中国河南省新密市孕妇巨细胞病毒(Cytomegalovirus, CMV)血清流行特征,及新生儿先天性CMV(CCMV)感染特征,为将来CCMV感染预防奠定基础。2015年至2017年,河南省新密市妇幼保健院开展了一项前瞻性队列研究,对于孕早期在本院进行建卡产检的孕妇连续招募入组,分别在孕早期、孕中期及孕晚期采集其血液标本进行CMV-IgG检测。孕妇分娩后,采集新生儿唾液和尿液标本开展CMV-DNA检测,进行CCMV筛查和确认性检测。新密市孕妇CMV抗体阳性率为97.80%(3594/3 675,95%CI:97.27%~98.25%),人群抗体阳性率、抗CMV~IgG抗体水平均随年龄有上升趋势。在抗体阳性孕妇中,孕早期IgG几何平均抗体浓度为11.10IU/mL(95%CI:10.80 IU/mL~11.41 IU/mL);在抗体阴性孕妇中,孕期抗体阳转率为11.39%(9/79,95%CI:4.39%~18.40%)。新密市CCMV估算感染率为1.33%(49.28/3694,95%CI:1.01%~1.76%),97.92%CCMV新生儿来自孕早期抗体阳性孕妇。河南省新密市孕妇CMV抗体阳性率极高,新生儿CCMV感染率也较高。CMV抗体阳性率与抗体水平均随着孕妇年龄有上升趋势。This study analyzed the characteristics of CMV seroprevalence in pregnant women, and congenital cytomegalovirus(CCMV) infection in newborns, to provide evidence for future CCMV infection control. From 2015 to 2017, a prospective cohort study was conducted in Xinmi Maternal and Child Health Hospital. Pregnant women at their first antenatal visits were consecutively enrolled and collected and blood samples were collected for CMV-IgG detection in the early, middle, and late stages of pregnancy. After delivery, saliva and urine of newborns were collected for CMV-DNA detection to screen and confirm CCMV infection. The CMV seroprevalence was 97.80%(3,594/3,675, 95%CI, 97.27%-98.25%) in pregnant women in Xinmi,China;both seroprevalence and IgG GMC increased with maternal age. In seropositive pregnant women, IgG GMC was 11.10 IU/mL(95%CI, 10.80-11.41 IU/mL) at early pregnancy;in seronegative pregnant women, the seroconversion rate was 11.39%(9/79, 95%CI, 4.39%-18.40%). The estimated CCMV incidence was 1.33%(49.28/3,694, 95%CI, 1.01%-1.76%). Additionally, 97.92% of CCMV newborns were from seropositive pregnant women. In Xinmi,China. the CMV seroprevalence in pregnant women was extremely high, and the CCMV prevalence in newborns was also relatively high. Both seroprevalence and IgG GMC increased with maternal age.

关 键 词：巨细胞病毒 先天性感染 流行病学 抗体 

分 类 号：R183.7[医药卫生—流行病学] R373.9[医药卫生—公共卫生与预防医学]