恶性肿瘤患者血型不规则抗体分布及输血疗效分析  

Analysis of Irregular Blood Group Antibody Distribution and Blood Transfusion Efficacy in Patients with Malignant Tumor

作　　者：任栋 赵宏斌 郭效君 贺雪花 REN Dong;ZHAO Hong-Bin;GUO Xiao-Jun;HE Xue-Hua(Department of Blood Transfusion,Shanxi Bethune Hospital,Taiyuan 030032,Shanxi Province,China)

机构地区：[1]山西白求恩医院输血科,山西太原030032

出　　处：《中国实验血液学杂志》2023年第1期209-214,共6页Journal of Experimental Hematology

基　　金：山西省卫生健康委科研课题(2021114)。

摘　　要：目的:探讨恶性肿瘤患者血型不规则抗体的分布情况,并分析其与患者输血疗效的关系。方法:选择2019年1月至2021年12月山西白求恩医院收治的5600例恶性肿瘤患者作为研究对象,全部患者均接受输血治疗,且输血前进行交叉配血试验,检测患者不规则抗体;观察患者血型不规则抗体分布,并分析其与患者输血疗效的关系。结果:5600例恶性肿瘤患者不规则抗体阳性96例,阳性率为1.71%;96例恶性肿瘤患者不规则抗体阳性主要涉及的血型系统为Rh、MNSs、Duffy系统,其中Rh血型最为常见,且以抗-E占比最高;血型不规则抗体阳性的恶性肿瘤患者中女性占比高于男性;年龄>60岁患者占比最高,其次为>40且≤50岁患者,18-30岁患者占比最低;血型不规则抗体阳性的恶性肿瘤患者以血液系统(包括淋巴瘤)、消化系统、生殖泌尿系统为主;输血无效组患者不规则抗体阳性率高于有效组,差异有统计学意义(P<0.05)。经logistics回归分析结果显示,不规则抗体阳性是恶性肿瘤患者输血无效的危险因素(OR>1,P<0.05)。结论:恶性肿瘤患者血型不规则抗体阳性以女性为多见,且年龄>60岁占比最高,主要分布于血液系统、消化系统、泌尿生殖系统恶性肿瘤,且血型不规则抗体阳性与患者输血疗效有关。Objective:To investigate the distribution of irregular blood group antibodies in patients with malignant tumors,and to analyze the relationship between it and efficacy of blood transfusion in patients.Methods:5600 patients with malignant tumors treated in Shanxi Bethune Hospital from January 2019 to December 2021 were selected as the research subjects.All patients received blood transfusion,and cross matching test was conducted before blood transfusion,irregular antibody results of patients were tested;the irregular distribution of blood group antibodies was observed,and the relationship between it and efficacy of blood transfusion in patients was analyzed.Results:Among 5600 patients with malignant tumors,96 cases were positive for irregular antibody,and the positive rate was 1.71%;the main blood group systems involved in the irregular antibody positive of 96 patients with malignant tumors were RH,MNSs and Duffy system,among which Rh blood group was the most common,and the proportion of anti-E was the highest;among the malignant tumor patients with positive blood group irregular antibody,the proportion of female was higher than that of male;the proportion of patients aged>60 years was the highest,followed by patients aged>40 and≤50 years,and the proportion of patients aged 18-30 years was the lowest;the patients with positive blood group irregular antibody were mainly in blood system(including lymphoma),digestive system,reproductive and urinary system;the positive rate of irregular antibody of patients in the ineffective group was higher than that of patients in the effective group,the difference was statistically significant(P<0.05).Logistic regression analysis results showed that,irregular antibody positive was a risk factor for ineffective blood transfusion in patients with malignant tumor(OR>1,P<0.05).Conclusion:The irregular blood group antibody positive of patients with malignant tumor are mostly female,and the proportion of patients aged>60 is the highest,which is mainly distributed in malignant tumors o

关 键 词：恶性肿瘤 血型不规则抗体 交叉配血试验 输血疗效 

分 类 号：R457.1[医药卫生—治疗学] R730[医药卫生—临床医学]