小梁网组织表面力学特性及其各向异性模型  

The Surface Mechanical Property of Trabecular Meshwork and its Anisotropic Model

作　　者：常金龙 王川 李坦[2,4] 闫义涛 韩苗苗[1,6] 刘志成 CHANG Jinlong;WANG Chuan;LI Tan;YAN Yitao;HAN Miaomiaol;LIU Zhicheng(Schoolof Medical Engineering,Xinxiang Medical University,Xinxiang453003,Henan,China;Bejing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,School of Biomedical Engineering,Capital Medical University,Bejing 100069,China;Yanjing Medical College,Capital Medical University,Bejing 100300,China;Shandong Eye Institute,Shandong First Medical University&Shandong Academy of Medical Sciences,Qingdao 266071,Shandong,China;Department of Ophthalmology,the First Affiliate Hospital of Xinxiang Medical University,Xinxiang 453199,Henan,China;Xinxiang Engineering Technology Research Center of Intelligent Rehabilitation Equipment,Xinxiang 453003,Henan,China)

机构地区：[1]新乡医学院医学工程学院,河南新乡453003 [2]首都医科大学生物医学工程学院,临床生物力学应用基础研究北京市重点实验室,北京100069 [3]首都医科大学燕京医学院,北京101300 [4]山东第一医科大学(山东省医学科学院)山东省眼科研究所所,山东青岛266071 [5]新乡医学院第一附属医院眼科,河南新乡453199 [6]新乡市智能康复设备工程技术研究中心,河南新乡453003

出　　处：《医用生物力学》2022年第6期1000-1005,共6页Journal of Medical Biomechanics

基　　金：河南省科技攻关项目(222102310483);临床生物力学应用基础研究北京市重点实验室开放课题(2022KF01)。

摘　　要：目的 探讨小梁网组织表面弹性模量的变化趋势,并使用各向异性模型模拟,验证各向异性模型的合理性。方法 对2只大鼠的4个小梁网样本在表面不同位置进行原子力显微镜(atomic force microscope, AFM)压痕实验,并使用本课题组提出的各向异性小梁网力学模型对小梁网组织表面不同位置处测得的弹性模量进行模拟实验。结果 测试得到的小梁网组织表面弹性模量会随着位置不同而变化,并且在小梁网中段达到最小值;各向异性小梁网力学模型可以较好地模拟这一现象。结论 各向异性小梁网力学模型在描述小梁网力学特性方面具有较强的理论意义与实用价值。同时,该模型可以解释对小梁网组织进行单轴拉伸与AFM压痕实验获得的弹性模量之间的巨大差别。因此,各向异性小梁网模型是对小梁网力学特性的一种更好描述。Objective The tendency of elastic modulus on trabecular meshwork(TM) surface was measured and numerical simulation was derived using an anisotropic model, so as to verify rationality of the anisotropic model. Methods Atomic force microscope(AFM) indentation tests were conducted on four TM samples from two rats at different locations, and simulation experiment was conducted to measure elastic modulus at different locations of TM surface based on the proposed anisotropic TM model. Results The tested TM elastic modulus varied at different test locations on TM surface and reached the minimum value in the middle of TM. The anisotropic TM model could reliably simulate this phenomenon. Conclusions The anisotropic TM mechanical model has strong theoretical significance and practical values in describing mechanical characteristics of TM. Meanwhile, the model can explain the huge differences in elastic modulus obtained by uniaxial stretch of TM tissues and by AFM indentation test. Therefore, the anisotropic TM model is a better description for TM mechanical properties.

关 键 词：小梁网 弹性模量 压痕测试 各向异性模型 

分 类 号：R318.01[医药卫生—生物医学工程]