可降解载药原位水凝胶在眼后段药物缓释的有限元分析  

Finite Element Analysis on Biodegradable Drug-Loaded in-situ Hydrogels for Sustained Release of Drugs in Posterior Eye

作　　者：竹鑫裕 段春争[1] 李红霞[1] 李洪林[2] ZHU Xinyu;DUAN Chunzheng;LI Hongxia;LLI Honglin(School of Mechanical Engineering,Dalian University of Technology,Dalian 116081,Liaoning,China;School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]大连理工大学机械工程学院,辽宁大连116081 [2]华东理工大学药学院,上海200237

出　　处：《医用生物力学》2022年第6期1026-1031,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11502044,U1906233);中央高校基本科研业务费专项资金(DUT17RC(3)104)。

摘　　要：目的探究在水凝胶的降解行为下药物在眼后段的扩散过程,为评估局部药物浓度和优化可降解水凝胶的眼内释药性能提供研究基础。方法通过有限元分析法建立可降解载药原位水凝胶在眼后段的药物传递模型。模型考虑水凝胶的降解作用、眼内压和视网膜色素上皮细胞主动吸收引起的对流作用,以及眼内吸收清除作用对药物扩散的影响,探究药物在眼后段中的浓度变化情况。结果释药过程中,眼内药物主要向后部扩散,载药水凝胶的释药速度明显慢于溶液药物。结论可降解水凝胶通过防止药物中心移动和限制凝胶内部药物扩散的方式延长药物在眼后段的停留时间,合理调整原位水凝胶注射位置和降解性能参数能有效提高其治疗效果。Objective To study the drug diffusion process in posterior eye under the biodegradation behavior of hydrogels,and to provide the research basis for evaluating local drug concentration and optimizing intraocular drug release performance of the biodegradable hydrogels.Methods Through finite element analysis,the drug delivery model of the biodegradable drug-loaded in-situ hydrogels in posterior eye was established.The effects of degradation of hydrogels,intraocular pressure and convection caused by active absorption of retinal pigment epithelial cells,as well as the effect of intraocular absorption and clearance on drug diffusion were considered to study the development of drug concentration in posterior eye.Results The intraocular drug diffused mainly to the posterior segment during drug release,and release rate of the drug-loaded hydrogels was significantly slower than that of the solution.Conclusions The biodegradable hydrogels prolong the residence time of drug in posterior eye by preventing movement of the drug center and limiting drug diffusion inside the hydrogels.Reasonable adjustment of the in-situ hydrogel injection position and degradation performance parameters can effectively improve its therapeutic effects.

关 键 词：可降解原位水凝胶 药物缓释 眼后段 

分 类 号：R318.01[医药卫生—生物医学工程]