胆囊三维建模与运动功能分析  

Three-Dimensional Modeling and Motor Function of Gallbladder

作　　者：张智惠 宋成利[1] 张凯[2] 胡海[2] ZHANG Zhihui;SONG Chengli;ZHANG Kai;HU Hai(Shanghai Institute for Minimally Invasive Therapy,School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Gallstone Center,Dongfang Hospital Affiliated to Tongji University,Shanghai 200120,China)

机构地区：[1]上海理工大学医疗器械与食品学院,现代微创医疗器械及技术教育部工程研究中心,上海200093 [2]同济大学附属东方医院胆石中心,上海200120

出　　处：《医用生物力学》2022年第6期1133-1137,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(51735003);上海市科研计划项目(18441900200);上海理工大学医工交叉基金。

摘　　要：目的 考虑在健康和病理情况下的胆囊特性,研究胆囊壁生物力学和胆汁流体力学特性,以及胆囊运动功能与胆结石成因的关系。方法 利用CT影像数据构建胆囊三维结构模型,建立有限元模型模拟胆囊运动和胆汁流动过程,分析不同的流固耦合条件下胆囊的运动模式以及对胆结石形成的影响。结果 在相同边界条件下,结石性胆汁流速(1.1 cm/s)比正常胆汁流速(2.3 cm/s)低;胆囊运动功能异常与否不会改变胆汁的流型,而胆汁成分改变使得流型更加曲折。运动功能较弱的胆囊整体所受最大应力为1.079 kPa、最大形变为0.931 mm,均远小于健康胆囊相对应的最大应力(4.318 kPa)和最大形变(3.725 mm)。在受力方面,胆汁成分异常并未对胆囊造成太大影响。结论 胆囊运动功能和生物力学特性密切相关。胆囊受损或衰退后,其收缩量会大幅减少,胆汁流动不畅,更易导致结石产生。胆囊的三维模型和运动功能分析可为胆结石手术治疗提供必要的理论基础和技术手段。Objective Considering the characteristics of gallbladder under healthy and pathological conditions, biomechanical properties of gallbladder wall and hydrodynamic characteristics of bile, as well as the correlation between motor function of gallbladder and genesis of gallstones were studied. Methods The three-dimensional(3D) structure model of gallbladder was constructed by using CT image data. The finite element model was established to simulate the movement of gallbladder and the flow process of bile, so as to analyze the movement mode of gallbladder and its influence on gallstones formation under different fluid-solid coupling conditions. Results Gallbladder motor function was closely related to biomechanical characteristics. Under the same boundary conditions, the flow velocity of calculous bile(1.1 cm/s) was lower than that of normal bile(2.3 cm/s). The abnormality of gallbladder motor function would not change the flow pattern of bile, but the change of bile composition would make the flow pattern more tortuous. The maximum stress and maximum deformation of gallbladder with weak motor function were 1.079 kPa and 0.931 mm, which were far smaller than the maximum stress(4.318 kPa) and maximum deformation(3.725 mm) of healthy gallbladder. In terms of stress, abnormal bile composition did not have much impact on gallbladder. Conclusions When the motor function of gallbladder is damaged and weakened, the contraction will be greatly reduced and gallstones are more likely to occur. The 3D model of gallbladder and analysis of motor function can provide necessary theoretical basis and technical means for surgical treatment of gallstones.

关 键 词：胆囊 三维建模 流固耦合 胆结石 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程]