Plectin与癌细胞迁移  

Plectin and Cancer Cell Migration

作　　者：徐茹霜 宋关斌[1] XU Rushuang;SONG Guanbin(College of Bioengineering,Chongqing University,Chongqing 400030,China)

机构地区：[1]重庆大学生物工程学院,重庆400030

出　　处：《医用生物力学》2022年第6期1177-1182,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11832008);重庆市自然科学基金项目(cstc2020jcyj-msxmX0545);中央高校基本科研业务费项目(2020CDJ-LHZZ-029)。

摘　　要：细胞迁移是细胞的一项基本生理活动,不仅在血管重建、炎症反应、组织发育、伤口愈合等方面发挥重要作用,还与癌细胞的侵袭转移有关。plectin(499~533 kDa)是在多种组织和细胞中广泛表达的一种大分子骨架蛋白,具有重要的生物学功能,参与细胞的多种生理病理过程。plectin可以通过调控细胞骨架影响迁移,也可以通过相关信号分子通路影响迁移。本文主要综述plectin在癌细胞迁移中的作用及其相关分子机制研究进展,为深入认识和研究plectin与癌细胞迁移的关系及其靶向干预提供理论参考。Cell migration is a basic physiological activity of cells. Cell migration not only plays an important role in vascular reconstruction, inflammatory response, tissue development, wound healing, etc., it is also related to the invasion and metastasis of cancer cells. Plectin(499-533 kDa) is a macromolecular skeleton protein widely expressed in various tissues and cells. It has important biological functions and participates in many physiological and pathological processes of cells. Plectin can affect migration by regulating the cytoskeleton and through related signaling pathways. This review focused on the role of plectin in cancer cell migration and its related molecular mechanisms, and provided the theoretical basis to further understand and study the relationship between plectin and cancer cell migration and its targeted intervention.

关 键 词：PLECTIN 细胞迁移 细胞骨架 癌细胞 

分 类 号：R318.01[医药卫生—生物医学工程]