国内外血液安全监测报告若干数据指标的比较与分析  

Comparison and Analysis of Indicators Data from Domestic and International Haemovigilance Reports

作　　者：谢东甫[1] 黄霞[2] 杨俊鸿[2] 孙洁[1] 张晰[1] 何涛[2] XIE Dong-fu;Huang Xia;YANG Jun-hong(Shanghai Blood Center,200051)

机构地区：[1]上海市血液中心,200051 [2]重庆市血液中心

出　　处：《临床输血与检验》2023年第1期16-20,共5页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：2021年度上海市卫生健康委临床研究专项(No.202140109);重庆市科卫联合医学科研重点项目(No.2022ZDXM031)资助。

摘　　要：目的通过对国内外血液安全监测(haemovigilance,HV)报告中若干指标性数据进行比较分析,阐述各HV系统的特点和当前血液安全基本状况,探讨国内HV工作的发展方向。方法国际HV报告来自英国、法国、荷兰、德国、日本、澳大利亚和美国等HV系统的2020年度报告,国内HV报告来自中国输血协会血液安全监测专业委员会发布的2020年度血液安全监测报告。从上述HV报告中选择若干指标型数据予以分析,包括献血不良反应、输血不良反应、输血传播感染、输血相关死亡和输血相关肺部并发症。结果各国献血不良反应发生率最低为0.0022%(英国),最高为3.2550%(澳大利亚);输血不良反应发生率最低为0.0141%(德国),最高为0.3580%(法国);输血传播感染发生率最低为百万分之0.72(英国),最高为百万分之14.33(澳大利亚);输血相关死亡发生率最低为百万分之0.77(澳大利亚),最高为百万分之11.47(英国)。结论在已建立了成熟有效的HV系统的国家或地区,输血是高度安全的。各HV系统监测范围和判定标准的不同使得相关数据呈现极大差异。相较于国际HV系统,国内HV数据尚不全面,较复杂输血不良反应如肺部并发症的报告不足。Objective Through comparative analysis of the domestic and international Haemovigilance(HV) report data,to describe the characteristics of each HV system and the current basic status of blood safety,and to explore the development direction of domestic HV work.Methods The international HV data were obtained from the 2020 annual reports of HV systems in the United Kingdom,France,the Netherlands,Germany,Japan,Australia and the United States,and the domestic HV reports were obtained from the 2020 HV report issued by the HV Committee of the Chinese Society of Blood Transfusion(CSBT).Several indicator data of the HV reports were analyzed,including adverse donation reactions,adverse transfusion reactions,transfusion-transmitted infections(TTI),transfusion-related fatalities,and transfusion-related pulmonary complications.Results That the incidences of adverse donation reactions ranged from a low of 0.0022%(UK)to a high of 3.2550%(Australia);the incidences of adverse transfusion reactions ranged from a low of 0.0141%(Germany)to a high of 0.3580%(France);the incidences of transfusion-transmitted infection from a low of 0.72 ppm(UK)to a high of 14.33 ppm(Australia);the incidences of transfusion-related fatality range from a low of 0.77 per million(Australia)to a high of 11.47per million(United Kingdom).Conclusion Blood transfusion is highly safe in countries or regions with well-established and effective HV systems.The differences in the monitoring scope and determination criteria of each HV system make the relevant data show great differences.Compared with international HV systems,domestic HV data are not yet comprehensive,and more complex transfusion adverse reactions such as pulmonary complications are underreported.

关 键 词：血液安全监测 献血不良反应 输血不良反应 输血传播感染 

分 类 号：R457[医药卫生—治疗学]