某三甲医院2021~2022年276例输血不良反应回顾性分析  

A Retrospective Analysis of 276 Adverse Transfusion Reactions in a Tertiary Hospital from 2021 to 2022

作　　者：周姗姗 荆亚楠 侯晓燕 薛亚飞 张媛媛[1] 黄霞[2] 王敏[1] ZHOU Shanshan;JING Ya-nan;HOU Xiao-yan(Department of Transfusion Medicine,the First Affiliated Hospital of Sciences and Technology of China,Hefei,Anhui 230001)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院),合肥230001 [2]重庆市血液中心

出　　处：《临床输血与检验》2023年第1期38-43,共6页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：重庆市科卫联合医学科研项目(No.2022ZDXM031)资助。

摘　　要：目的分析本院临床受血者发生输血不良反应的情况及其相关因素,为我院提供科学、安全的输血措施。方法通过临床输血管理系统统计本院2021年1月~2022年9月进行输血治疗的总人次,收集此时间段患者发生输血不良反应的例数及类别,分析受血者发生输血不良反应与年龄、性别、输血史、输注的血液成分、疾病类型等的关系。结果期间接受输血治疗92377人次,发生输血不良反应276例,输血不良反应总发生率为0.30%,血小板不良反应发生率最高(0.70%),其次为新鲜冰冻血浆和悬浮红细胞(0.50%和0.31%)。红细胞、血小板和血浆非溶血性发热反应的发生率分别为0.11%、0.05%和0.004%,过敏反应分别为0.06%(红细胞)、0.64%(血小板)和0.16%(血浆)。悬浮红细胞的非溶血性发热反应发生率(0.23%)高于去白细胞悬浮红细胞(0.04%),过敏反应发生率无差别(0.06%和0.07%);新鲜冰冻血浆(0.50%)过敏反应发生率高于其他血浆制品;浓缩血小板(1.09%)不良反应发生率高于单采血小板(0.65%)。输血不良反应发生率最高的科室为血液内科,其次为肾移植科。不同年龄、有无输血史、输注不同血液成分患者输血不良反应发生率差异均有统计学意义,不同性别的患者输血不良反应发生率比较,差异无统计学意义。结论输血不良反应的发生与输注的血液成分以及患者本身因素有关,临床输血时应综合多因素,选择合适的血液品种,减少输血不良反应的发生;同时医院应完善输血不良反应上报体系,加强医护人员输血相关知识培训,增强输血不良反应上报意识。Objective To provide scientific and safe blood transfusion measures for our hospital,we analyzed the adverse reactions of blood transfusion among clinical blood recipients and their related factors.Methods Through the clinical blood transfusion management system,we counted the total number of people who received blood transfusion treatment in our hospital from January 2021 to September 2022.At the same time,we collected the number and types of patients with adverse blood transfusion reactions during this period,and analyzed the relationship between adverse blood transfusion reactions and age,gender,blood transfusion history,blood components transfused,disease types,etc.Results We found that 92377 people received blood transfusion treatment during this period,and 276 of that experienced adverse transfusion reactions.The total incidence of adverse reactions to blood transfusion was 0.30%,of which the incidence of adverse reactions to platelets was the highest(0.70%),followed by fresh frozen plasma and suspended red blood cells(0.50%and 0.31%).The incidence of non hemolytic febrile reaction of red blood cells,platelets and plasma was 0.11%,0.05%and 0.004%respectively,and the allergic reaction was 0.06%(red blood cells),0.64%(platelets)and 0.16%(plasma)respectively.The incidence of non hemolytic febrile reaction of suspended red blood cells(0.23%)was higher than that of leukocyte depleted suspended red blood cells(0.04%).but there was no difference in the incidence of allergic reaction between the two components(0.06%and 0.07%).The incidence of allergic reaction in fresh frozen plasma(0.50%)was higher than that in other plasma products;and the adverse reaction rate of platelet concentrate(0.65%)was higher than that of apheresis platelets(1.09%).The department with the highest incidence of adverse reactions of blood transfusion was the Department of Hematology,followed by the Department of Renal Transplantation.We found that there were statistically significant differences in the incidence of adverse reactions to bloo

关 键 词：临床输血 输血不良反应 非溶血性发热反应 过敏反应 

分 类 号：R457[医药卫生—治疗学]