探讨高血压对慢性阻塞性肺疾病急性加重患者发生低钠血症的影响  

Investigation on the Effect of Hypertension on Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：吴琪茵[1] 胡妙芬[1] 黄雅萍 曾惠雪[1] 张良基 WU Qiyin;HU Miaofen;HUANG Yaping;ZENG Huixue;ZHANG Liangji(Department of Respiratory and Critical Care Medicine,Zhangzhou Hospital,Fujian Province,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建省漳州市医院呼吸与危重症医学科,福建漳州363000

出　　处：《中外医疗》2022年第28期1-4,共4页China & Foreign Medical Treatment

基　　金：福建医科大学启航基金(2019QH1280)。

摘　　要：目的探讨高血压是否作为慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期老年患者低钠血症的影响因素。研究分析低钠血症严重程度是否与高血压分级相关。方法回顾性分析福建省漳州市医院2019年10月—2021年10月收治的582例老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床资料。应用二分类Logistic回归分析明确高血压是否作为AECOPD低钠血症的影响因素。应用Spearman秩相关分析低钠血症严重程度与高血压分级的相关性。结果582例老年AECOPD患者中,其中134例出现低钠血症(23.0%)。高血压为老年住院AECOPD患者患低钠血症的危险因素(OR=1.685,P<0.05),无高血压患者患低钠血症是有高血压患者的0.593倍。低钠血症严重程度与高血压等级具有正相关关系(r=0.084)。结论合并有高血压的老年AECOPD患者更易出现低钠血症,患者在住院及门诊随访期间均需注意预防及控制电解质紊乱出现,此类高血压患者不应该随意控制钠盐的摄入。Objective To investigate whether hypertension is an influencing factor of hyponatremia in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Analysis of whether the severity of hyponatremia is associated with hypertension grade.Methods The clinical data of 582 elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)treated in the Zhangzhou Hospital of Fujian Province from October 2019 to October 2021 were retrospectively analyzed.Binary Logistic regression analysis was used to determine whether hypertension was an influencing factor of hyponatremia in AECOPD.The Spearman rank correlation was used to analyze the correlation between the severity of hyponatremia and the classification of hypertension.Results Among 582 elderly patients with AECOPD,134 had hyponatremia(23.0%).Hypertension was a risk factor for hyponatremia in elderly hospitalized AECOPD patients(OR=1.685,P<0.05).Hyponatremia was 0.593 times higher in patients without hypertension than in patients with hypertension.Hyponatremia severity was positively correlated with hypertension grade(r=0.084).Conclusion Elderly AECOPD patients with hypertension are more likely to develop hyponatremia,and patients should pay attention to preventing and controlling electrolyte disturbance during inpatient and outpatient follow-up.Such hypertensive patients should not arbitrarily control sodium intake.

关 键 词：慢性阻塞性肺疾病 高血压 低钠血症 

分 类 号：R4[医药卫生—临床医学]