阿托伐他汀联合经皮桡动脉穿刺介入术治疗老年冠心病患者的临床效果及对患者炎症因子水平的影响  

The Clinical Effect of Atorvastatin Combined with Percutaneous Transradial Intervention Therapy on Elderly Patients with Coronary Heart Disease and the Influence on Inflammatory Factors

作　　者：陈传琳 王强[1] CHEN Chuanlin;WANG Qiang(Medical District,908 Hospital of Joint Logistics Support Force,Yingtan 335000,China;不详)

机构地区：[1]中国人民解放军联勤保障部队第九〇八医院鹰潭医疗区,江西鹰潭335000

出　　处：《中国医学创新》2023年第3期5-9,共5页Medical Innovation of China

摘　　要：目的:探讨阿托伐他汀联合经皮桡动脉穿刺介入术(PTI)治疗老年冠心病患者的临床效果及对患者炎症因子水平的影响。方法:选择中国人民解放军联勤保障部队第九〇八医院鹰潭医疗区2018年1月-2019年7月收治的老年冠心病患者120例。按照治疗方法分为对照组和观察组,每组60例。对照组给予PTI治疗,观察组在对照组基础上给予阿托伐他汀治疗。比较两组支架植入情况,治疗前及术后1周心输出量(CO)、左室射血分数(LVEF)、左室舒张末期内径(LVDD)及收缩期末内径(LVSD)、内皮素-1(ET-1)、内皮细胞特异性分子-1(ESM-1)、超敏C反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)变化及疗效情况。结果:两组支架植入数比较差异无统计学意义(P>0.05);治疗前,两组CO、LVEF、LVDD、LVSD、ET-1、ESM-1、hs-CRP、TNF-α比较差异均无统计学意义(P>0.05);术后1周,两组CO、LVEF均升高,LVDD、LVSD、ET-1、ESM-1、hs-CRP、TNF-α均降低(P<0.05);观察组术后1周CO、LVEF均高于对照组,LVDD、LVSD、ET-1、ESM-1、hs-CRP、TNF-α均低于对照组(P<0.05);观察组总有效率96.67%高于对照组的86.67%(P<0.05);随访6个月,观察组不良心血管事件总发生率6.67%低于对照组的18.33%(P<0.05)。结论:阿托伐他汀联合PTI可显著改善冠心病患者心功能及血管内皮功能,降低机体炎症程度,减少术后不良心血管事件。Objective:To investigate the clinical effect of Atorvastatin combined with percutaneous transradial intervention therapy(PTI)in elderly patients with coronary heart disease and the influence on the levels of inflammatory factors.Method:A total of 120 elderly patients with coronary heart disease admitted to Medical District,908 Hospital of Joint Logistics Support Force from January 2018 to July 2019 were selected.According to the treatment method,they were divided into control group and observation group,with 60 cases in each group.PTI was given to the control group,and Atorvastatin was given to the observation group on the basis of the control group.The stent implantation,cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVDD)and end systolic diameter(LVSD),endothelin-1(ET-1),endothelial cell specific molecule-1(ESM-1),hypersensitive C reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)before and after treatment and curative effect were compared.Result:There was no significant difference in the number of stent implantation between the two groups(P>0.05);before treatment,there were no significant differences in CO,LVEF,LVDD,LVSD,ET-1,ESM-1,hs-CRP,TNF-αbetween the two groups(P>0.05);one week after operation,CO and LVEF increased,LVDD,LVSD,ET-1,ESM-1,hs-CRP,TNF-αdecreased in both groups(P<0.05);one week after operation,CO and LVEF of the observation group were higher than those of the control group,LVDD,LVSD,ET-1,ESM-1,hs-CRP and TNF-αwere lower than those of the control group(P<0.05);the total effective rate of the observation group was 96.67%,which was higher than 86.67%of the control group(P<0.05);the total incidence of adverse cardiovascular events in the observation group was 6.67%,which was lower than 18.33%of the control group(P<0.05).Conclusion:Atorvastatin combined with PTI can significantly improve the heart function and vascular endothelial function of patients with coronary heart disease,reduce the degree of body inflammation,and reduce the ad

关 键 词：阿托伐他汀 经皮桡动脉穿刺介入术 冠心病 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]