加味左金丸联合西药治疗反流性食管炎临床研究  

Clinical Study on Modified Zuojin Pills Combined with Western Medicine for Reflux Esophagitis

作　　者：王利芳 楼东东 WANG Lifang;LOU Dongdong

机构地区：[1]浙江老年关怀医院,浙江杭州310015

出　　处：《新中医》2022年第24期54-58,共5页New Chinese Medicine

基　　金：杭州市医药卫生科技项目(20220938)。

摘　　要：目的:观察加味左金丸联合常规西药治疗反流性食管炎(RE)的疗效。方法:将82例RE肝胃郁热证患者纳入研究,按随机数字表法分为治疗组与对照组各41例,2组均给予枸橼酸莫沙必利片、奥美拉唑肠溶胶囊治疗,治疗组加服加味左金丸治疗,2组均治疗4周。治疗前后评定肝胃郁热证症状积分、胃镜分级,检测胃肠道自主神经功能指标[低频功率(LF)值、高频功率(HF)值]。评估2组的临床疗效。结果:治疗后,治疗组临床疗效总有效率(95.12%)高于对照组(80.49%)(P<0.05)。2组肝胃郁热证症状积分均低于治疗前(P<0.05),治疗组肝胃郁热证症状积分低于对照组(P<0.05)。2组胃黏膜改善情况均优于治疗前(P<0.01),治疗组胃黏膜改善情况优于对照组(P<0.05)。2组LF值均高于治疗前,HF值均低于治疗前,差异均有统计学意义(P<0.05);治疗组LF值高于对照组,HF值低于对照组,差异均有统计学意义(P<0.05)。结论:加味左金丸联合西药治疗RE肝胃郁热证患者疗效确切,可有效缓解临床症状,修复胃黏膜,调节胃肠道自主神经功能。Objective:To observe the curative effect of the therapy of modified Zuojin Pills combined with routine western medicine on reflux esophagitis(RE). Methods:A total of 82 RE patients with liver and stomach depression-heat syndrome were divided into the treatment group and the control group according to the random number table method, with 41 cases in each group. Both groups were treated with Mosapride Citrate Tablets and Omeprazole Enteric-Coated Capsules, and the treatment group was additionally treated with modified Zuojin Pills. Both groups were treated for four weeks. Before and after treatment,the symptom scores of liver and stomach depression-heat syndrome and rating of gastroscope were evaluated. The indexes of gastrointestinal autonomic nerve function, including low-frequency(LF)power and high-frequency(HF) power, were detected. The clinical effects in the two groups were evaluated. Results:After treatment,the total clinical effective rate was 95.12% in the treatment group,higher than that of 80.49% in the control group(P<0.05). The symptom scores of liver and stomach depression-heat syndrome in the two groups were lower than those before treatment(P<0.05),and the above score in the treatment group was lower than that in the control group(P<0.05). The improvement in gastric mucosa in the two groups was better than that before treatment(P<0.01),and the improvement in the treatment group was better than that in the control group(P<0.05). The values of LF in the two groups were higher than those before treatment,and the values of HF were lower,differences being significant(P<0.05);the value of LF in the treatment group was higher and the value of HF in the treatment group was lower than that in the control group,differences being significant(P<0.05). Conclusion:The therapy of modified Zuojin Pills combined with western medicine has a definite curative effect on RE patients with liver and stomach depression-heat syndrome,which can effectively relieve the clinical symptoms,repair the gastric mucosa,and regulate

关 键 词：反流性食管炎 肝胃郁热证 加味左金丸 胃肠道自主神经功能 胃镜分级 

分 类 号：R259[医药卫生—中西医结合]