Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway  

作　　者：WANG Mengru TIAN Baopeng SHEN Jie XU Shilin LIU Cong GUAN Ling GUO Min DOU Jie 

机构地区：[1]College of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China

出　　处：《Chinese Journal of Natural Medicines》2023年第1期36-46,共11页中国天然药物（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.81472233);the“Double First-Class”University Project(No.CPU2018GF/GY16);the“111 Project”from the Ministry of Education of China;the Project Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.

摘　　要：Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia,and exhibits anti-bacterial,anti-inflammatory,anti-tumor and lipid-lowering activities.Recent attention has gradually drawn on bavachin-induced apoptosis in many human cancer cell lines.However,the anti-cancer effects and related mechanisms in colorectal cancer remain unknown.Here,we investigated the effects of bavachin on colorectal cancer in vivo and in vitro.The results showed that bavachin inhibited the proliferation of human colorectal cancer cells and induce apoptosis.These changes were mediated by activating the MAPK signaling pathway,which significantly up-regulated the expression of Gadd45a.Furthermore,Gadd45a silencing obviously attenuated bavachin-mediated cell apoptosis.Inhibition of the MAPK signaling pathway by JNK/ERK/p38 inhibitors also weakened the up-regulation of Gadd45a by bavachin.The anticancer effect of bavachin was also validated using a mouse xenograft model of human colorectal cancer.In conclusion,these findings suggest that bavachin induces the apoptosis of colorectal cancer cells through activating the MAPK signaling pathway.

关 键 词：Bavachin APOPTOSIS Colorectal cancer GADD45A MAPK 

分 类 号：R965[医药卫生—药理学]