重组人干扰素α-2b治疗老年病毒性肝炎的效果及对肝功能及血清TNF-α、IGF-Ⅰ水平的影响  

Therapeutic effects of recombinant human interferon α-2b on elderly patients with viral hepatitis and its influence on liver function, serum levels of TNF-α and IGF-Ⅰ

作　　者：窦文静 陈爱萍 屈丹丹 Dou Wenjing;Chen Aiping;Qu Dandan(Department of Infectious Diseases,Puyang People’s Hospital,Puyang 457000,China;Department of Internal Medicine,the First Hospital of Qingfeng,Qingfeng 457300,China)

机构地区：[1]濮阳市人民医院感染性疾病科,濮阳457000 [2]清丰县第一医院内科,清丰457300 [3]濮阳市人民医院感染科,濮阳457000

出　　处：《中国实用医刊》2022年第22期98-101,共4页Chinese Journal of Practical Medicine

摘　　要：目的探究重组人干扰素α-2b(rhIFNα-2b)治疗老年病毒性肝炎的效果及对患者肝功能及血清肿瘤坏死因子-α(TNF-α)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)的影响。方法抽取2020年3月至2022年4月濮阳市人民医院收治的老年病毒性肝炎患者120例,以随机数字表法分为对照组与干扰素组,每组60例。对照组给予常规治疗,干扰素组在常规治疗基础上给予rhIFNα-2b。比较两组治疗前后的肝功能、T淋巴细胞亚群、血清TNF-α、IGF-Ⅰ水平,评估疗效并记录患者并发症发生情况。结果治疗后,干扰素组血清总胆红素、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平均低于对照组(P均<0.05);治疗后,干扰素组血清TNF-α、IGF-Ⅰ水平低于对照组(P<0.05);治疗后,干扰素组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。干扰素组总有效率(90.00%,54/60)高于对照组(75.00%,45/60),P<0.05;干扰素组肝肾综合征、肝性脑病、消化道出血发生率均低于对照组(P均<0.05)。结论给予老年病毒性肝炎患者重组人干扰素α-2b,可显著下调其血清TNF-α、IGF-Ⅰ水平,改善肝功能及免疫力,降低相关并发症发生率,提升临床疗效。Objective To investigate the effect of recombinant human interferonα-2b(rhIFNα-2b)therapy on elderly patients with viral hepatitis,and its influence on liver function,and serum tumor necrosis factor-α(TNF-α)and insulin-like growth factor-Ⅰ(IGF-Ⅰ).Methods A total of 120 elderly patients with viral hepatitis treated in Puyang People’s Hospital from March 2020 to April 2022 were selected,and they were divided into control group and interferon group by random number table method,with 60 cases in each group.The control group was treated by conventional treatment,and the interferon group was treated with rhIFNα-2b based on the conventional treatment.The liver function,T lymphocyte subsets,serum TNF-αlevel and IGF-Ⅰlevel were compared between the two groups before and after treatment.The curative effect was evaluated,and the incidence of complications was recorded.Results After treatment,the levels of serum total bilirubin,alanine aminotransferase and aspartate aminotransferase in the interferon group were significantly lower than those in the control group(all P<0.05);after treatment,levels of serum TNF-αand IGF-Ⅰin the interferon group were lower than those in the control group(P<0.05);after treatment,the cluster of differentiation 4+(CD4+),CD4+/cluster of differentiation 8+(CD8+)in the interferon group were significantly higher than those in the control group,while CD8+was significantly lower than that in the control group(P<0.05).The effective rate of the interferon group(90.00%,54/60)was significantly higher than that in the control group(75.00%,45/60),P<0.05.The incidence of hepatorenal syndrome,hepatic encephalopathy and gastrointestinal bleeding in the interferon group were significantly lower than those in the control group(all P<0.05).Conclusions Administration of rhIFNα-2b to elderly patients with viral hepatitis can significantly down-regulate the levels of serum TNF-αand IGF-Ⅰ,improve liver function and immunity,reduce the incidence of related complications,and improve clinical efficacy

关 键 词：病毒性肝炎 老年人 重组人干扰素Α-2B 肿瘤坏死因子-α 肝功能 胰岛素样生长因子-Ⅰ 

分 类 号：R512.6[医药卫生—内科学]