经皮穴位电刺激联合药物治疗膀胱过度活动症的疗效观察及对患者焦虑抑郁的影响  

Efficacy observation of transcutaneous electrical acupoint stimulation combined with medication in treating overactive bladder and its impact on patient’s anxiety and depression

作　　者：王舟怡 黄桂晓[1] 杨亚梅 陈虹历 WANG Zhouyi;HUANG Guixiao;YANG Yamei;CHEN Hongli(Shenzhen Luohu People's Hospital,Shenzhen 518000,China;Shenzhen Luohu District Hospital of Traditional Chinese Medicine,Shenzhen 518021,China)

机构地区：[1]深圳市罗湖区人民医院,深圳518000 [2]深圳市罗湖区中医院,深圳518021

出　　处：《上海针灸杂志》2023年第2期153-157,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：深圳罗湖区软科学研究计划项目(LX20200907)。

摘　　要：目的观察经皮电刺激委阳穴联合口服琥珀酸索利那新片治疗膀胱过度活动症的临床疗效及对患者焦虑和抑郁状态的影响。方法将143例膀胱过度活动症患者随机分为对照组(49例)、试验组(48例)和假刺激组(46例)。3组均予口服琥珀酸索利那新片治疗,试验组另予经皮电刺激委阳穴,假刺激组另予与试验组相同的贴片但未进行电刺激。比较3组治疗前后每日尿失禁发作、紧急事件、夜尿发作、膀胱过度活动症症状量表、焦虑自评量表、抑郁自评量表及生命质量测定量表的评分变化,比较3组治疗后排尿次数和临床疗效,比较3组不良反应发生情况。结果试验组总有效率优于其余两组(P<0.05)。3组治疗后每日尿失禁发作、紧急事件、夜尿发作、膀胱过度活动症症状量表、焦虑自评量表、抑郁自评量表及生命质量测定量表的评分均优于同组治疗前(P<0.05),且试验组均优于其余两组(P<0.05)。治疗后,试验组排尿次数明显少于其余两组(P<0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论经皮电刺激委阳穴联合口服琥珀酸索利那新片治疗膀胱过度活动症可有效减少排尿次数,改善患者症状、焦虑和抑郁状态及生活质量,疗效优于单一口服药物治疗。Objective To observe the clinical efficacy of transcutaneous electrical acupoint stimulation(TEAS)at Weiyang(BL39)combined with Solifenacin succinate tablets in treating overactive bladder and its impact on patient’s anxiety and depression state.Method A total of 143 patients with overactive bladder were randomly divided into a control group(49 cases),a trial group(48 cases),and a sham stimulation group(46 cases).Oral administration of Solifenacin succinate tablets was given to all three groups.In addition,the trial group received TEAS at Weiyang,and the same patches were applied in the sham stimulation group but without electrical stimulation.Changes in the daily incontinence attack,emergency,nocturia attack,overactive bladder symptom score,self-rating anxiety scale,self-rating depression scale,and quality of life scales were observed in the three groups.After treatment,urination frequency,clinical efficacy,and adverse reactions were compared among the three groups.Result The total effective rate was higher in the trial group than in the other two groups(P<0.05).The daily incontinence attack,emergency,nocturia attack,overactive bladder symptom score,self-rating anxiety scale,self-rating depression scale,and quality of life scales scores all improved after treatment in the three groups(P<0.05);the trial group outperformed the other two groups(P<0.05).After treatment,the urination frequency was markedly lower in the trial group than in the other two groups(P<0.05).There were no significant differences in the adverse reaction rate among the three groups(P>0.05).Conclusion TEAS at Weiyang combined with oral administration of Solifenacin succinate tablets can effectively reduce urination frequency,improve patients’symptoms,anxiety and depression state,and quality of life,and produce more significant efficacy than oral medication alone.

关 键 词：穴位疗法 经皮穴位电刺激 穴 委阳 膀胱过度活动症 焦虑 抑郁 

分 类 号：R246.1[医药卫生—针灸推拿学]