肿瘤坏死因子受体超家族成员TNFRSF19的研究进展  

Progress in tumor necrosis factor receptor superfamily member TNFRSF19

作　　者：马廷政 汪徐春 孙玉洁[1,2] MA Tingzheng;WANG Xuchun;SUN Yujie(Department of Cell Biology,School of Basic Medicine,Nanjing Medical University,Nanjing 211126,China;Key laboratory of Human Functional Genomics of Jiangsu Province,Nanjing Medical University,Nanjing 211126,China)

机构地区：[1]南京医科大学基础医学院细胞生物学系,江苏南京211166 [2]南京医科大学江苏省人类功能基因组学重点实验室,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2023年第1期100-106,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82072580)。

摘　　要：肿瘤坏死因子受体超家族(tumor necrosis factor receptor superfamily,TNFRSF)通过与肿瘤坏死因子超家族成员相互作用调节免疫应答,调控细胞生存、增殖和分化等。TNFRSF19是TNFRSF家族的新成员之一,主要表达于上皮细胞、毛囊和大脑组织细胞中。近年来相关研究表明,TNFRSF19在调节神经系统发育和维持干细胞干性中发挥重要生理功能。TNFRSF19在不同肿瘤中发挥截然相反的促癌或抑癌功能,其功能与肿瘤的组织来源密切相关。本文就TNFRSF19的生理功能及其在癌症中的最新研究进展进行简要综述。The tumor necrosis factor receptor superfamily(TNFRSF)interacts with members of the tumor necrosis factor superfamily(TNFSF)to play fundermental roles in regulating immune responses,cell survival,proliferation and differentiation.TNFRSF19 is a new member of the TNFRSF family,mainly expressed in epithelial cells,hair follicles and brain tissue cells.In recent years,studies have shown that TNFRSF19 plays an important physiological function in regulating the development of the nervous system and maintaining the stemness of stem cells.TNFRSF19 plays diametrically opposite functions of tumor-promoting or tumorsuppressing in different tumors,and its functions are closely related to the tissue origin of tumors.This article briefly reviews the physiological function of TNFRSF19 and its latest research progress in cancer.

关 键 词：肿瘤坏死因子受体超家族 肿瘤坏死因子超家族 TNFRSF19 

分 类 号：R392.11[医药卫生—免疫学]