基于隐结构结合Apriori关联规则探析原发性肝癌方药规律  

A Study on Prescription Rules of Primary Liver Cancer Based on Implicit Structure Combined with Apriori Association Rules

作　　者：吴晓红 陈诗雨 叶明君 朱婷 刘竹青 李白坤[1] 朱继民[3] WU Xiao-hong;CHEN Shi-yu;YE Ming-jun;ZHU Ting;LIU Zhu-qing;LI Bai-kun;ZHU Ji-min(School of Traditional Chinese Medicine,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China;School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China;College of LifeSciences,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China)

机构地区：[1]安徽中医药大学中医学院,安徽合肥230012 [2]安徽中医药大学药学院,安徽合肥230012 [3]安徽中医药大学生命科学学院,安徽合肥230012

出　　处：《贵州中医药大学学报》2023年第1期52-58,共7页Journal of Guizhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目,项目编号:81903953;安徽省自然科学基金项目,项目编号:2208085MH279;安徽高校省级自然科学研究项目,项目编号:KJ2019A0460;安徽中医药大学自然科学研究重点项目,项目编号:2021zrzd06;安徽中医药大学人才支持计划,项目编号:2022rcyb027。

摘　　要：目的:探析中医药治疗原发性肝癌方药分布以及中药配伍规律,旨在为临床辨证用药提供参考。方法:以(中医、证候、证型、中药或方剂)和(肝癌、肝肿瘤、肝恶性肿瘤、肝腺癌、肝细胞癌、原发性肝癌和肝积)为主题词,从中国知网、中国生物医学文献知识库、维普、万方数据库中检索建库至2022年4月15日收录的中医药治疗肝癌文献。提取合格文献信息并建立数据库,使用Excel 2021、Lantern5.0及SPSS Molder14.1等软件分析方药规律。结果:最终纳入合格文献618篇,涉及中药398味,累计频次7832次。使用中药频次由高到低依次为白术、茯苓、甘草、黄芪、柴胡、白花蛇舌草等,以补虚药、活血化瘀药、清热药等居多。对频次≥20的75味中药物分析发现,方药以甘、苦、辛味,平、寒、温性药,归脾、肝、肺经者居多。隐树模型学习得到隐变量20个,隐类40个,结合专业知识归纳为9个综合聚类模型,11个核心方剂;推断出原发性肝癌常见证型有气滞血瘀证、肝气郁滞证、肝胆湿热证、邪阻少阳证、肝肾阴虚证、脾虚肝旺证、肾阴亏虚证、脾虚食积证、毒热内蕴证9个中医证候。关联规则分析得出37条关联规则,包括2条两项强关联规则:茯苓→白术、党参→白术;35条三项强关联规则:党参+茯苓→白术、当归+党参→白术、半枝莲+茯苓→白术等。结论:治疗肝癌的方药注重用活血化瘀,清热疏肝利湿等消法清除癌毒同时辅以健脾益气等扶正固本类中药,即健脾滋阴益肾固其本,清热利湿活血治其标。Objective: To investigate the distribution and compatibility of Chinese medicine prescription for treating primary liver cancer, in order to provide reference for clinical medication based on syndrome differentiation. Methods: Literature on the treatment of liver cancer with traditional Chinese medicine(TCM) was retrieved from China National Knowledge Infrastructure(CNKI), China Biomedical Literature Knowledge Base(CBM), VIP and Wanfang Database from the establishment of the database to April 15, 2022 by using keywords, such as traditional Chinese medicine, syndrome, syndrome type, traditional Chinese medicine or formula, liver cancer, liver tumor, liver malignant tumor, liver adenocarcinoma, hepatocellular carcinoma, primary liver cancer and hepatic volume. Qualified literature information was extracted and a database was established. Excel 2021, Lantern5.0 and SPSS Molder14.1 were used to analyze the prescription rules. Results: 618 qualified literates were included, involving 398 Chinese herbal medicines, with a cumulative frequency of 7832 times. The frequencies of Chinese herbal medicines used were, in descending order, Atractylodes macrocephala, Poria, Glycyrrhiza, Astragalus, Radix Bupleurum, and Rhizoma Polygonati, mainly with the functions of supplementing deficiency, activating blood and transforming stasis, and clearing heat. The analysis of the 75 Chinese medicines with frequencies ≥20 revealed that the prescriptions were mostly of the flavors of sweet, bitter, acridity, with balanced, cold and warm nature, which belong to the spleen, liver and lung meridians. Hidden tree model learning yielded 20 hidden variables and 40 hidden classes, which were summarized into 9 comprehensive clustering models and 11 core prescriptions by combining professional knowledge. The common symptoms of primary liver cancer include Qi stagnation and blood stasis, liver qi stagnation, liver and gall bladder damp heat, evil blocking Shaoyang, liver and kidney yin deficiency, spleen deficiency and liver vigour, kidney yin de

关 键 词：原发性肝癌 中医药 隐结构 关联规则 方药规律 

分 类 号：R273[医药卫生—中西医结合]