高敏C-反应蛋白、同型半胱氨酸、内皮微粒及血压波动在高血压合并阻塞性睡眠呼吸暂停低通气综合征患者中的表达水平及临床意义  

Expression Levels and Clinical Significance of High-sensitivity C-reactive Protein,Homocysteine,Endothelial Particles and Blood Pressure Fluctuations in Patients with Hypertension Combined with Obstructive Sleep Apnea Hypoventilation Syndrome

作　　者：孙英霞[1] 关林[1] SUN Yingxia;GUAN Lin(Department of Respira tory Medicine,Jilin Provincial People's Hospital,Changchun,Jilin Province,130021 China)

机构地区：[1]吉林省人民医院呼吸科,吉林长春130021

出　　处：《系统医学》2022年第22期6-9,共4页Systems Medicine

摘　　要：目的高敏C-反应蛋白、同型半胱氨酸、内皮微粒及血压波动在高血压合并阻塞性睡眠呼吸暂停低通气综合征患者中的表达水平及临床意义。方法在2019年3月—2021年3月期间在吉林省人民医院进行治疗的高血压患者中随机抽取100例进行研究,按照是否合并阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea-hypopnea syndrome,OSAHS),将患者分为A组(单纯高血压)和B组(高血压合并OSAHS),各50例,比较两组患者高敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)和内皮微粒(EMP)水平以及血压波动,并分析上述指标与高血压合并OSAHS的关系。结果A组的hs-CRP为(357.63±154.40)mg/L、Hcy为(10.17±2.75)μmol/L、EMP为(760.12±38.70)个/μl低于B组的(778.33±225.71)mg/L、(13.57±2.45)μmol/L,(900.42±89.12)个/μl,差异有统计学意义(t=10.878、6.527、10.211,P<0.05);治疗后,B组患者的白昼SBP(134.35±4.71)mmHg,DBP(117.65±7.64)mmHg和夜间SBP(89.62±6.78)mmHg,DBP(81.37±5.75)mmHg明显低于A组的白昼SBP(142.33±4.13)mmHg,DBP(126.57±5.93)mmHg和夜间SBP(95.19±3.45)mmHg,DBP(86.12±3.22)mmHg,差异有统计学意义(P<0.05);高血压合并OSAHS患者Hcy、CRP、EMP与白天SBP均呈正相关(P<0.05)。结论高血压合并阻塞性睡眠呼吸暂停低通气综合征患者的hs-CPR、Hcy和EMP均比较高,且hsCRP、Hcy和EMP的变化会影响到患者的血压变化。Objective The expression levels and clinical significance of high-sensitivity C-reactive protein,homocysteine,endothelial particles and blood pressure fluctuations in patients with hypertension combined with obstructive sleep apnea hypoventilation syndrome.Methods From March 2019 to March 2021,100 hypertensive patients treated in Jilin Provincial People’s Hospital were randomly selected for study.The patients were divided into group A(hypertension alone)and group B(hypertension combined with OSAHS)according to whether they were combined with obstructive sleep apnea hypoventilation syndrome(OSAHS),with 50 cases in each group.The levels of high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy)and endothelial particles(EMP)and blood pressure fluctuations were compared between the two groups.The relationship between these indicators and hypertension combined with OSAHS was also analyzed.Results The hs-CRP,Hcy and EMP in group A were(357.63±154.40)mg/L,(10.17±2.75)μmol/L and(760.12±38.70)/μl,which were lower than(778.33±225.71)mg/L,(13.57±2.45)μmol/L and(900.42±89.12)/μl in group B,and the differences were statistically significant(t=10.878,6.527,10.211,P<0.05).After treatment,daytime SBP(134.35±4.71)mmHg,DBP(117.65±7.64)mmHg and nighttime SBP(89.62±6.78)mmHg,DBP(81.37±5.75)mmHg in group B were significantly lower than those in group A(142.33±4.13)mmHg,DBP(126.57±5.93)mmHg and nighttime SBP(95.19±3.45)mmHg,DBP(86.12±3.22)mmHg,the difference was statistically significant(P<0.05);Hcy,CRP and EMP were positively correlated with daytime SBP in patients with hypertension and OSAHS(P<0.05).Conclusion Patients with hypertension combined with obstructive sleep apnea hypoventilation syndrome had higher hsCPR,Hcy and EMP,and the changes of hs-CRP,Hcy and EMP would affect the changes of blood pressure in patients.

关 键 词：高敏C-反应蛋白 同型半胱氨酸 内皮微粒 血压变化 高血压 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R544[医药卫生—心血管疾病]