3项肿瘤标志物对良恶性胸腹腔积液的鉴别诊断价值  

The Value of Three Tumor Markers for the Differential Diagnosis of Benign and Malignant Thoracoabdominal Effusions

作　　者：蒋新华[1] 刘道彦[2] 王丽[1] JIANG Xinhua;LIU Daoyan;WANG Li(Department of Laboratory,Xuzhou First People's Hospital,Xuzhou,Jiangsu Province,221000 China;Department of Laboratory,Xuzhou Maternal and Child Health Hospital,Xuzhou,Jiangsu Province,221000 China)

机构地区：[1]江苏省徐州市第一人民医院检验科,江苏徐州221000 [2]江苏省徐州市妇幼保健院检验科,江苏徐州221000

出　　处：《系统医学》2022年第22期84-87,共4页Systems Medicine

摘　　要：目的探讨3项肿瘤标志物对良恶性胸腹腔积液的鉴别诊断价值。方法采用病例对照研究法,选取徐州市第一人民医院2020年11月—2021年7月收治的267例胸腹腔积液患者,其中包括经临床确诊的癌症患者154例(恶性组)和良性病变患者113例(良性组)。应用电化学发光法对血清和胸腹水中癌胚抗原(CEA)、角质蛋白19片段(CYFRA21-1)和神经元特异性烯醇化酶(NSE)进行检测。对比两组血清和胸腹水中CEA、CYFRA21-1、NSE水平,并比较血清CEA、CYFRA21-1、NSE三种肿瘤标志物联合检测与单独检测的诊断效能。结果恶性组血清中CEA、CYFRA21-1、NSE水平均高于良性组,差异有统计学意义(t=3.74、4.01、3.20,P<0.05);同时CEA、CYFRA21-1、NSE检测结果在恶性组胸腹水中均高于良性组,差异有统计学意义(t=7.08、3.83、2.61,P<0.05)。血清CEA、CYFRA21-1、NSE3种肿瘤标志物联合检测的灵敏度高于血清CEA、CYFRA21-1、NSE 3种肿瘤标志物单独检测的灵敏度,差异有统计学意义(χ^(2)=52.38、18.93、42.45,P<0.01)。结论肿瘤标志物检测对临床诊断治疗具有重要价值。Objective To investigate the differential diagnostic value of three tumor markers for benign and malignant thoracoabdominal effusions.Methods Using the case-control study method,267 patients with pleural and peritoneal effusion admitted to Xuzhou First People’s Hospital from November 2020 to July 2021 were selected,including 154 patients with clinically confirmed cancer(malignant group)and 113 patients with benign lesions(benign group).Electrochemiluminescence was applied to detect carcinoembryonic antigen(CEA),keratin 19 fragment(CYFRA21-1)and neuron-specific enolase(NSE)in serum and thoracoabdominal fluid.The levels of CEA,CYFRA21-1 and NSE in serum and pleural and ascitic fluid were compared between the two groups,and the diagnostic efficacy of the combined detection and independent detection of CEA,CYFRA21-1 and NSE in serum was compared.Results Serum CEA,CYFRA21-1 and NSE levels in malignant group were higher than those in benign group,and the difference was statistically significant(t=3.74,4.01,3.20,P<0.05).The results of CEA,CYFRA21-1 and NSE were higher in the malignant group than in the benign group in the thoracoabdominal fluid,and the difference was statistically significant(t=7.08,3.83,2.61,P<0.05).The sensitivity of the combined assay of serum CEA,CYFRA21-1 and NSE tumor markers was higher than that of serum CEA,CYFRA21-1 and NSE tumor markers alone,and the difference was statistically significant(χ^(2)=52.38,18.93,42.45,P<0.01).Conclusion Tumor marker detection is of great value for clinical diagnosis and treatment.

关 键 词：胸腹腔积液 肿瘤标志物 脱落细胞 

分 类 号：R4[医药卫生—临床医学]