连续性肾脏替代疗法联合异甘草酸镁注射液对重症急性胰腺炎患者炎症及预后疗效评价  

Evaluation of the Inflammatory and Prognostic Efficacy of Continuous Renal Replacement Therapy Combined with Magnesium Isoglycyrrhizate Injection in Patients with Severe Acute Pancreatitis

作　　者：黄一赫 HUANG Yihe(Department of Emergency Medicine,North District,Qiqihar Hospital of Traditional Chinese Medicine,Qiqihar,Hei-longjiang Province,161000 China)

机构地区：[1]齐齐哈尔市中医院北区急诊内科,黑龙江齐齐哈尔161000

出　　处：《系统医学》2022年第22期120-123,共4页Systems Medicine

基　　金：齐齐哈尔市科学技术计划项目任务(SFZD-2019202)。

摘　　要：目的评价连续性肾脏替代疗法(continuous renal replacement therapy,CRRT)联合异甘草酸镁注射液对重症急性胰腺炎(severe acute pancreatitis,SAP)患者炎症及预后疗效的影响。方法随机将2020年3月—2021年9月齐齐哈尔市中医院急诊科收治的50例SAP患者分为对照组和观察组,各25例,对照组采用常规治疗+CRRT治疗,观察组采用常规治疗+CRRT治疗+异甘草酸镁注射液治疗,比较两组患者治疗前后的临床治疗效果、炎症介质水平及预后。结果观察组治疗有效率为88.00%,显著高于对照组64.00%,差异有统计学意义(χ^(2)=3.947,P<0.05);治疗2周后,两组患者的炎性因子相关指标(PCT、CRP、IL-6、IL-10、TNF-α)均显著下降且观察组降低幅度要显著大于对照组,观察组患者ICU住院时间、腹腔感染率及ICU病死率均显著低于对照组,差异有统计学意义(P<0.05)。结论CRRT联合异甘草酸镁注射液治疗SAP疗效确切,能降低炎性因子水平,抑制病情发展,改善预后,值得临床广泛推广应用。Objective To evaluate the effect of continuous renal replacement therapy(CRRT)combined with magnesium isoglycyrrhizate injection on the inflammation and prognosis of patients with severe acute pancreatitis(SAP).Methods 50 SAP patients admitted to the emergency department of Qiqihar Hospital of Traditional Chinese Medicine from March 2020 to September 2021 were randomly divided into control group and observation group,with 25 patients in each group.The control group was treated with conventional treatment+CRRT.The observation group was treated with conventional treatment+CRRT treatment+magnesium isoglycyrrhizate injection,and the clinical treatment effect,inflammatory mediator level and prognosis of patients in both groups were compared before and after treatment.Results The treatment efficiency of the observation group was 88.0%,which was significantly higher than that of the control group 64.00%,the difference was statistically significant(χ^(2)=3.947,P<0.05).After 2 weeks of treatment,the inflammatory factor-related indexes(PCT,CRP,IL-6,IL-10,TNF-α)in two groups decreased significantly and the decrease in the observation group was significantly greater than that in the control group,the length of ICU stay,abdominal infection rate and ICU death rate of patients in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion CRRT combined with magnesium isoglycyrrhizate injection is effective in treating SAP,reducing the level of inflammatory factors,inhibiting the development of the disease and improving the prognosis,and is worthy of wide clinical application.

关 键 词：连续性肾脏替代疗法 异甘草酸镁注射液 重症急性胰腺炎 炎症 

分 类 号：R4[医药卫生—临床医学]