妊娠中晚期HBV感染孕妇T细胞水平及与妊娠结局的相关性研究  

Study on T-cell Levels in Pregnant Women with HBV Infection in Mid to Late Pregnancy and Correlation with Pregnancy Outcome

作　　者：陈武玲 黄慧慧[1] 朱焕金[1] 鞠爱萍[1] CHEN Wuling;HUANG Huihui;ZHU Huanjin;JU Aiping(Guangzhou Huadu District Maternal and Child Health Hospital,Guangzhou,Guangdong Province,510800 China)

机构地区：[1]广州市花都区妇幼保健院,广东广州510800

出　　处：《系统医学》2022年第22期178-181,共4页Systems Medicine

基　　金：广州市花都区科技计划项目(19-HDWS-084)。

摘　　要：目的探讨妊娠中晚期乙型肝炎病毒(hepatits B virus,HBV)感染孕妇T细胞水平及对妊娠结局的影响。方法选取2020年5月—2021年3月于广州市花都区妇幼保健院就诊的HBV感染孕妇80例作为研究组。同时将研究组孕妇根据乙型肝炎E抗原(HBeAg)是否阳性分为两组,HBeAg(+)38例,HBeAg(-)42例。另外同期随机选取正常孕妇40名作为对照组。比较3组CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)比值水平;同时比较孕妇妊娠结局及与T细胞水平的相关性。结果研究组HBeAg(+)孕妇CD4^(+)及CD4^(+)/CD8^(+)比值显著低于HBeAg(-)孕妇及对照组,CD8^(+)水平显著高于HBeAg(-)孕妇及对照组,差异有统计学意义(P<0.001);HBeAg(+)孕妇剖宫产、胎膜早破、早产等不良妊娠结局显著高于HBeAg(-)孕妇及对照组,差异有统计学意义(P<0.05);HBeAg(+)孕妇中CD4^(+)及CD4^(+)/CD8^(+)比值与剖宫产、胎膜早破、早产呈负相关(r=-0.416、P=0.017;r=-0.508、P=0.012;r=-0.557、P=0.009;r=-0.436、P=0.015;r=-0.521、P=0.011;r=-0.596、P=0.008),CD8^(+)与剖宫产、胎膜早破、早产呈正相关(r=0.398、P=0.027;r=0.413、P=0.017;r=0.482、P=0.013)。结论妊娠中晚期HBV感染孕妇中,HBeAg(+)孕妇T细胞水平有明显变化,妊娠期应注意HBV感染孕妇HBeAg状态及T细胞水平变化,配合临床检测与适当治疗改善妊娠结局。Objective To investigate the T-cell levels of pregnant women with hepatitis B virus(hepatits B virus,HBV)infection in mid to late pregnancy and the effect on pregnancy outcome.Methods Eighty pregnant women with HBV infection attending the Guangzhou Huadu District Maternal and Child Health Hospital from May 2020 to March 2021 were included as the study group.The pregnant women in the study group were also divided into two groups according to whether they were positive for hepatitis B E antigen(HBeAg),with 38 cases of HBeAg(+)and 42 cases of HBeAg(-).In addition,40 normal pregnant women were randomly selected as the control group during the same period.The levels of CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)ratios were compared in the three groups;the pregnancy outcomes of the pregnant women and the correlation with T-cell levels were also compared.Results The CD4^(+)and CD4^(+)/CD8^(+)ratios of HBeAg(+)pregnant women in the study group were significantly lower than those of HBeAg(-)pregnant women and the control group,and the CD8^(+)levels were significantly higher than those of HBeAg(-)pregnant women and the control group,the difference was statistically significant(P<0.001).The incidence of adverse pregnancy outcomes such as cesarean delivery,premature rupture of membranes and preterm delivery were significantly higher in HBeAg(+)pregnant women than in HBeAg(-)pregnant women and the control group,the difference was statistically significant(P<0.05).CD4^(+)and CD4^(+)/CD8^(+)ratios among HBeAg(+)pregnant women were negatively correlated with cesarean delivery,premature rupture of membranes,and preterm delivery(r=-0.416,P=0.017;r=-0.508,P=0.012;r=-0.557,P=0.009;r=-0.436,P=0.015;r=-0.521,P=0.011;r=-0.596,P=0.008).CD8^(+)was positively associated with cesarean delivery,premature rupture of membranes,and preterm delivery(r=0.398,P=0.027;r=0.413,P=0.017;r=0.482,P=0.013).Conclusion Among pregnant women with HBV infection in the middle and late stages of pregnancy,there are significant changes in T-cell levels in HBeAg(+)pregna

关 键 词：孕妇 HBV T细胞 妊娠结局 妊娠中晚期 

分 类 号：R59[医药卫生—内科学]