结合分枝杆菌感染者辅助性Th2型细胞因子IL-4、IL-6、IL-10的水平变化  

Changes of Helper Th2 Cytokines IL-4,IL-6 and IL-10 Levels in Patients with Mycobacterium Tuberculosis Infection

作　　者：杨晓悦 李毓龙 罗仲秋 朱紫衣 YANG Xiao-yue;LI Yu-long;LUO Zhong-qiu;ZHU Zi-yi(Department of Laboratory Medicine,the People’s Hospital of Jianyang City,Jianyang 641400,Sichuan,China)

机构地区：[1]简阳市人民医院实验医学科,四川简阳641400

出　　处：《医学信息》2023年第1期113-116,共4页Journal of Medical Information

基　　金：简阳市人民医院科研课题(编号:JY202022、JY202135)。

摘　　要：目的通过检测结核患者、隐性结核杆菌感染者及健康人群的Th2型细胞因子白细胞介素4(IL-4)、白细胞介素6(IL-6)、白细胞介素10(IL-10)的变化,筛选潜伏性感染者,以进行早期治疗和防护。方法选择简阳市人民医院2020年2月-2021年2月已确诊的活动性肺结核患者、潜伏性感染者及健康对照者各30例,分别作为活动性结核患者组(ATB组)、结核潜伏感染者组(LTBI组)、对照组,均进行结核感染T细胞检测,使用液相悬浮芯片技术测定血清中IL-4、IL-6、IL-10水平,比较三组IL-4、IL-6、IL-10水平。结果ATB组、LTBI组、对照组IL-4水平依次增高,其中ATB组IL-4水平低于LTBI组和对照组,且LTBI组IL-4水平低于对照组,差异均有统计学意义(P<0.05);TB组、LTBI组、对照组IL-6水平依次降低,其中ATB组IL-6水平高于LTBI组,但差异无统计学意义(P>0.05);ATB组和LTBI组IL-6水平均高于对照组,差异有统计学意义(P<0.05);ATB组、LTBI组、对照组IL-10水平依次增高,其中ATB组IL-10水平低于LTBI组和对照组,差异有统计学意义(P<0.05);LTBI组IL-10水平低于对照组,但差异无统计学意义(P>0.05)。结论Th2型细胞因子IL-4、IL-10的水平变化可以区分活动性肺结核与潜伏性肺结核,临床可通过监测其水平对潜伏性结核感染者进行早期干预和治疗。Objective To study the changes of Th2 cytokines interleukin-4(IL-4),interleukin-6(IL-6)and interleukin-10(IL-10)in patients with tuberculosis,latent tuberculosis infection and healthy people,and to screen latent infection for early treatment and protection.Methods From February 2020 to February 2021,30 patients with active pulmonary tuberculosis,30 patients with latent tuberculosis infection and 30 healthy controls were selected from the People’s Hospital of Jianyang City as active tuberculosis group(ATB group),latent tuberculosis infection group(LTBI group)and control group,respectively.The T cells of tuberculosis infection were detected.The levels of IL-4,IL-6 and IL-10 in serum were measured by magnetic luminex screening assay.The levels of IL-4,IL-6 and IL-10 in the three groups were compared.Results The levels of IL-4 in ATB group,LTBI group and control group increased in turn,while the level of IL-4 in ATB group was lower than that in LTBI group and control group,and the level of IL-4 in LTBI group was lower than that in control group(P<0.05).The levels of IL-6 in TB group,LTBI group and control group decreased in turn,while the level of IL-6 in ATB group was higher than that in LTBI group,but the difference was not statistically significant(P>0.05);the levels of IL-6 in ATB group and LTBI group were higher than those in control group(P<0.05).The levels of IL-10 in ATB group,LTBI group and control group increased in turn,while the level of IL-10 in ATB group was lower than that in LTBI group and control group(P<0.05);the level of IL-10 in LTBI group was lower than that in control group,but the difference was not statistically significant(P>0.05).Conclusion The changes of Th2 cytokines IL-4 and IL-10 levels can distinguish active pulmonary tuberculosis from latent pulmonary tuberculosis.Early intervention and treatment of latent tuberculosis infection can be carried out by monitoring their levels.

关 键 词：肺结核 结核分枝杆菌 白细胞介素4 白细胞介素6 白细胞介素10 

分 类 号：R52[医药卫生—内科学]