电刺激干预骨代谢相关信号通路研究进展  

Research progress of electrical stimulation on bone metabolism-related signaling pathways

作　　者：黄委委 李鼎鹏 李宁[1] 韩宪富 林德民 李建国 丁聚贤 谢兴文 HUANG Weiwei;LI Dingpeng;LI Ning;HAN Xianfu;LIN Demin;LI Jianguo;DING Juxian;XIE Xingwen(Gansu University of Chinese Medicine,Lanzhou 730000;The Second People,s Hospital of Gansu Province,Lanzhou 730030;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省第二人民医院,甘肃兰州730000 [3]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2023年第2期242-247,共6页Chinese Journal of Osteoporosis

基　　金：中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台;国家自然基金地区项目(82160911,81860864);甘肃省青年科技基金计划(20JR5RA129);中央高校基本科研业务费项目(31920210041);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05);甘肃省第二人民医院院内重点项目(YNZD2021-2)。

摘　　要：骨质疏松症(osteoporosis, OP)作为一种患病率逐年递增的临床上常见的全身代谢性疾病,其发病机制与多种信号通路及分子相关。大量动物实验及分子研究分析发现,电刺激引起的电流变化能通过多种直接或间接途径激活成骨细胞(osteoblast, OB)、破骨细胞(osteoclasts, OC),从而促进骨细胞生长。因此合理介导电刺激激活或抑制相关信号通路及分子水平或许是未来深入、系统探究骨质疏松症发病机制及治疗的有效手段。本文旨在总结电刺激与OP发病相关信号通路及分子之间的影响并加以阐述、总结,为OP治疗提供一些新的思路。Osteoporosis(OP) is a common systemic metabolic bone disease with increasing prevalence year by year. Its pathogenesis is related to a variety of signaling pathways and molecules. A large number of animal experiments and molecular studies have found that the current changes caused by electrical stimulation can activate osteoblast(OB) and osteoclast(OC) through a variety of direct or indirect ways, thus promoting the growth of osteoblasts. Therefore, it may be an effective way to explore the pathogenesis and treatment of osteoporosis in the future. The purpose of this paper is to summarize the effects of electrical stimulation on OP related signaling pathways and molecules, and to provide some ideas for the treatment of Osteoporosis.

关 键 词：电刺激 骨质疏松症 信号通路 生长因子 

分 类 号：R681[医药卫生—骨科学] R285.6[医药卫生—外科学]