平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展  

Application progress of parallel artificial membrane permeation assay model in drug permeability screening of transdermal drug delivery system

作　　者：宋三孔[1] 白银亮[1] 梁建娣[1] SONG Sankong;BAI Yinliang;LIANG Jiandi(Dept.of Pharmacy,the Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院药剂科,兰州730030

出　　处：《中国药房》2023年第4期502-507,共6页China Pharmacy

基　　金：甘肃省科技计划项目(No.20JR5RA313)。

摘　　要：传统的Franz扩散池法一直是评价经皮给药系统(TDDS)药物渗透性的“金标准”,但在大量药物分子的高通量筛选方面,其存在效率低、成本高、离体皮肤不易获得、可靠性差、工作量大等缺点。平行人工膜渗透(PAMPA)模型的出现,为现有TDDS药物渗透性的评价提供了可靠的前期预测数据。PAMPA模型现已广泛应用于镇痛药、局部麻醉药、抗氧剂、解热镇痛抗炎药、维生素类、胆碱酯酶抑制剂、天然产物活性成分等TDDS药物及其制剂的渗透性筛选研究,具有可靠性高、重复性好、效率高、成本低、数据稳定等特点。PAMPA模型极大地提高了TDDS药物渗透性的高通量筛选效率,随着该模型的大量应用和逐步成熟,该模型将成为传统评价模型之外的一种新型有效的评价方法。The traditional model Franz diffusion cell method has always been the“gold standard”for evaluating the permeability of transdermal drug delivery system(TDDS)drug.However,in the high throughput screening of a large number of drug molecules,it has the disadvantages of low efficiency,high cost,difficulty to obtain isolated skin,poor reliability and large workload.The emergence of parallel artificial membrane permeation assay(PAMPA)model provides reliable pre-prediction data for the evaluation of permeability of TDDS drug.PAMPA model has been widely used in the permeability screening research of TDDS drugs and their preparations such as analgesics,local anesthetics,antioxidants,antipyretics,analgesics and anti-inflammatory drugs,vitamins,cholinesterase inhibitors,active ingredients of natural products,and has the characteristics of high reliability,good selectivity,high efficiency,low cost and data stability.PAMPA model has greatly improved the high throughput screening efficiency of TDDS drug permeability.With the extensive application and gradual maturity of this model,it will become a new and effective evaluation method in addition to the traditional evaluation model.

关 键 词：经皮给药系统 平行人工膜渗透 药物渗透性筛选 

分 类 号：R943[医药卫生—药剂学]