脂质体药物递送系统研究进展及临床应用  

Research progress and clinical application of liposomal drug delivery system

作　　者：谷文睿 杨雅 马欢 夏培元 GU Wenrui;YANG Ya;MA Huan;XIA Peiyuan(Dept.of Pharmacy,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China;Dept.of Pharmacy,Children’s Hospital of Chongqing Medical University,Chongqing 400015,China)

机构地区：[1]陆军军医大学第一附属医院药学部,重庆400038 [2]重庆医科大学附属儿童医院药学部,重庆400015

出　　处：《中国药房》2023年第4期508-512,共5页China Pharmacy

基　　金：重庆英才计划(No.CQYC201903088)。

摘　　要：脂质体制剂因具有高效、低毒和靶向等特点,已成为国内外新型药物制剂的研究热点。本文从脂质体的制备方法、分类和临床应用等方面综述近年来的研究进展。结果显示,在制备工艺方面,为了获得更稳定可控的脂质体,学者们在传统制备方法的基础上改进优化,建立了超临界流体法、冷冻干燥法和双不对称离心法等新型制备方法。为实现增强疗效的同时降低毒性的目的,学者们对传统脂质体进行优化,开发出环境敏感型脂质体、长循环脂质体和多功能脂质体等改良脂质体,极大地推动了脂质体在临床的应用。目前脂质体制剂已经在抗肿瘤、抗感染、疫苗等多个领域获得临床应用,但大部分新型脂质体还处于早期的开发阶段。With the advantage of high efficiency,low toxicity and targeting,liposomes have become the research hotspot of new drug preparations at home and abroad.In this paper,the research progress in recent years is reviewed from the aspects of preparation methods,classification and clinical application of liposomes.The results showed that in order to obtain more stable and controllable liposomes,scholars improved and optimized the traditional preparation methods and established novel preparation methods such as supercritical fluid methods,freeze-drying method and double-asymmetric centrifugation method.In order to enhance the efficacy and reduce toxicity,the conventional liposomes were optimized to get novel ones such as environmentally sensitive liposomes,long-circulating liposomes and multifunctional liposomes,which had greatly promoted the clinical application of liposomes.For now,liposomes have been used in many fields,such as anti-cancer agents,antimicrobial and vaccines,but most of the new liposomes are still in the early stage of development.

关 键 词：脂质体 药物递送系统 抗肿瘤 抗感染 疫苗 

分 类 号：R943[医药卫生—药剂学]