甲亢患者^(99)mTcO_(4)^(-)甲状腺SPECT检查的周围剂量当量率分析  

Ambient dose equivalent in^(99)mTcO_(4)^(-)single photon emission computed tomography of the thyroid among patients with hyperthyroidism

作　　者：胡隽[1] 刘浩 施燕琴[1] 俞苏英 窦超[1] 赵岚 王菲菲 董孟杰[1] HU Jun;LIU Hao;SHI Yanqin;YU Suying;DOU Chao;ZHAO Lan;WANG Feifei;DONG Mengjie(Department of Nuclear Medicine,The First Affiliated Hospital of School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China)

机构地区：[1]浙江大学医学院附属第一医院核医学科,浙江杭州310003

出　　处：《预防医学》2023年第2期152-154,共3页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：目的了解甲状腺功能亢进症(甲亢)患者行^(99)mTcO_(4)^(-)甲状腺SPECT检查的周围剂量当量率变化,提供辐射防护指导建议。方法选择某三级甲等医院行^(99)mTcO_(4)^(-)甲状腺SPECT检查的甲亢患者为研究对象,在注射^(99)mTcO_(4)^(-)后的不同时间、与患者颈部水平不同距离处检测周围剂量当量率,采用广义线性混合模型分析注药后时间、检测距离、甲状腺24 h摄碘率和甲状腺质量对周围剂量当量率的影响。结果纳入100例甲亢患者,其中男性24例,女性76例;年龄为(38.5±14.0)岁。广义线性混合模型有统计学意义(F=6610.165,P<0.001);患者甲状腺质量、注药后时间、检测距离对周围剂量当量率的影响有统计学意义(F=57.967、15988.574、11200.645,均P<0.001),周围剂量当量率与患者甲状腺质量呈正相关,与注药后时间、检测距离呈负相关。结论甲亢患者^(99)mTcO_(4)^(-)甲状腺SPECT检查的周围剂量当量率受患者的甲状腺质量、注射后时间和检测距离的影响,推迟与患者接触的时间或与患者保持距离可以有效防护辐射。Objective To investigate the changes of ambient dose equivalent rate in^(99)mTcO_(4)^(-)single photon emission computed tomography(SPECT)of the thyroid among patients with hyperthyroidism,so as to provide insights into radiation protection guidance.Methods Patients with hyperthyroidism who underwent^(99)mTcO_(4)^(-)SPECT of the thyroid in a tertiary hospital were enrolled.The ambient dose equivalent rate was measured at different time points following^(99)mTcO_(4)^(-)infection and at sites with different distances from patients’neck,and the effects of time post-injection,distance from patients’neck,24-hour thyroidal radioiodine uptake and thyroid weight on the ambient dose equivalent rate were examined using a generalized linear mixed model.Results Totally 100 patients with hyperthyroidism were enrolled,including 24men and 76 women and with a mean age of(38.5±14.0)years.The generalized linear mixed model was statistically significant(F=6610.165,P<0.001),and patients’thyroid weight,time post-injection and distance from patients’neck significantly affected the ambient dose equivalent rate(F=57.967,15988.574,11200.645,all P<0.001),and the ambient dose equivalent rate positively correlated with patients’thyroid weight and negatively correlated with time post-injection and distance from patients’neck.Conclusions The ambient dose equivalent rate is affected by patients’thyroid weight,time post-injection and distance from patients’neck among patients with hyperthyroidism undergoing^(99)mTcO_(4)^(-)SPECT of the thyroid.Delay in contact with patients or keeping distance from patients may be effective for radiation protection.

关 键 词：甲状腺功能亢进症 SPECT 辐射防护 剂量当量率 

分 类 号：R581.1[医药卫生—内分泌]