耳穴贴压联合中药改善糖尿病前期的Meta分析  

Meta-analysis ofauricular plaster therapy combined with traditional Chinese medicine for pre-diabetes

作　　者：杨琦[1] 荆鲁[2] 王紫雯 李梓荣 杨俏丽 李金埕 覃锦 刘尚建[1] Qi Yang;Lu Jing;Ziwen Wang;Zirong Li;Qiaoli Yang;Jincheng Li;Jin Qin;Shangjian Liu(Department of Clinical Laboratory,Dongzhimen Hospital,Bejing University of Chinese Medicine,Bejing 100700,China;Department of Internal Medicine,Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]北京中医药大学东直门医院检验科,北京100700 [2]中国中医科学院眼科医院内科,北京100040

出　　处：《湖南师范大学学报（医学版）》2022年第6期113-118,共6页Journal of Hunan Normal University(Medical Sciences)

基　　金：国家重点研发计划(2019YFC1710101)。

摘　　要：目的:系统评价在生活方式干预的基础上使用耳穴贴压及耳穴贴压联合中药两种方式改善糖尿病前期的临床疗效.方法:收集耳穴贴压干预糖尿病前期的随机对照试验(RCTs),检索时间为建库至2021年5月,采用RevMan5.3进行耳穴贴联合中药改善糖尿病前期的Meta分析.结果:共纳入10篇RCT,涉及患者994例.根据不同干预措施进行亚组分析(耳穴贴压亚组、耳穴贴压联合中药亚组),结果显示:(1)耳穴贴压亚组在降低空腹血糖[MD=-0.57,95%CI(-0.86,-0.28),P=0.0001]、餐后2小时血糖[MD=-0.87,95%CI(-1.19,-0.58),P<0.00001]、糖化血红蛋白[SMD=-0.87,95%CI(-1.52,-0.22),P=0.008]方面优于对照组.(2)耳穴贴压联合中药亚组在降低空腹血糖[MD=-0.54,95%CI(-0.72,-0.36),P<0.00001]、餐后2小时血糖[MD=-1.15,95%CI(-1.73,-0.57),P=0.0001]、糖化血红蛋白[SMD=-0.78,95%CI(-1.05,-0.51),P<0.00001]方面优于对照组.敏感性分析显示结果稳定性较好.结论:无论是否联合中药,耳穴贴压对糖尿病前期的改善均优于对照组且疗效显著,两者结果无显著性差异.Objective To systematically evaluate the clinical efficacy of auricular point sticking and auricular point sticking combined with traditional Chinese medicine in improving prediabetes on the basis of lifestyle intervention. Methods Randomized controlled trials(RCTs) on the intervention of auricular point sticking on prediabetes were collected. The retrieval time was from the establishment of the database to May 2021. RevMan5.3 was used to conduct a meta-analysis on the improvement of auricular point sticking combined with traditional Chinese medicine on prediabetes. Results A total of 10 RCTS were included, involving 994 patients. Subgroup analysis was conducted according to different intervention measures(auricular point sticking subgroup, auricular point sticking combined with traditional Chinese medicine subgroup), and the results showed that:(1) In the auricular point sticking subgroup, fasting blood glucose [MD=-0.57, 95%CI(-0.86,-0.28), P=0.0001] and 2-hour postprandial blood glucose [MD=-0.87, 95%CI(-1.19,-0.58) ] were significantly lower than those in the auricular point sticking subgroup. P<0.00001] and glycosylated hemoglobin [SMD=-0.87, 95%CI(-1.52,-0.22), P=0.008] were better than those of the control group.(2) In the subgroup of auricular point sticking combined with traditional Chinese medicine, fasting blood glucose [MD=-0.54, 95%CI(-0.72,-0.36), P<0.00001] and 2-hour postprandial blood glucose [MD=-1.15, 95%CI(-1.73,-0.57) ] were significantly decreased. P=0.0001] and glycosylated hemoglobin [SMD=-0.78, 95%CI(-1.05,-0.51),P<0.00001] were better than those of the control group. Sensitivity analysis showed that the results were stable. Conclusion Whether combined with Chinese medicine or not, auricular point sticking is superior to the control group in the improvement of prediabetes, and the effect is significant, there is no significant difference between the two results.

关 键 词：耳穴贴压 糖尿病前期 血糖指标 META分析 

分 类 号：R245.9[医药卫生—针灸推拿学]