洛阳地区肥胖学龄前儿童2型糖尿病的流行病学特点及发病影响因素分析  

Epidemiological characteristics and influencing factors of occurrence of type 2 diabetes mellitus in preschool children with obesity in Luoyang

作　　者：张小白[1] 卢亚亚[2] 刘静 Zhang Xiaobai;Lu Yaya;Liu Jing(Department of Pediatrics,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Child Care,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Pediatrics,Luoyang Maternal and Child Health Care Hospital,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院儿科,洛阳471000 [2]河南科技大学第一附属医院儿保科,洛阳471000 [3]洛阳市妇幼保健院儿科,洛阳471000

出　　处：《中国实用医刊》2022年第21期24-28,共5页Chinese Journal of Practical Medicine

摘　　要：目的探讨洛阳地区肥胖学龄前儿童2型糖尿病(T2DM)的流行病学特点及发病的影响因素。方法抽取2018年2月至2021年12月河南科技大学第一附属医院进行健康体检的洛阳地区常住的200例学龄前肥胖儿童资料进行调查,分析流行病学情况,根据T2DM检出情况将其分为T2DM组(52例)和非T2DM组(148例)。采用Logistic回归分析影响洛阳地区肥胖学龄前儿童T2DM发病的相关因素。结果纳入的200例肥胖学龄前期儿童中,确诊T2DM患儿52例,患病率为26.00%(52/200)。流行病学调查结果显示,洛阳地区肥胖学龄前儿童T2DM发病年龄主要集中在6~7岁(90.38%,47/52),男童发病率较高(73.08%,38/52),肥胖度≥40%者占比为55.77%(29/52),顺产占比(67.31%,35/52)高于剖宫产(32.69%,17/52),人工喂养占比(51.92%,27/52)相对较高,母亲妊娠期糖尿病或肥胖学龄前儿童合并黑棘皮病、存在明显T2DM家族史时,肥胖学龄前儿童T2DM患病率明显升高;肥胖学龄前儿童T2DM发病与其年龄、性别、肥胖度、合并母亲妊娠期糖尿病、黑棘皮病和T2DM家族史有关(P<0.05);T2DM组洛阳地区肥胖学龄前儿童空腹血糖、糖化血红蛋白水平高于非T2DM组(P<0.05);Logistic回归分析发现,性别、肥胖度、黑棘皮病和T2DM家族史均为影响洛阳地区肥胖学龄前儿童T2DM发病的相关因素(P<0.05)。结论洛阳地区肥胖学龄前儿童T2DM检出率较高,性别、肥胖度、黑棘皮病、T2DM家族史等是影响本地区肥胖学龄前儿童T2DM发病的危险因素。Objective To investigate the epidemiological characteristics and influencing factors of occurrence of type 2 diabetes mellitus(T2DM)in preschool children with obesity in Luoyang.Methods The data of 200 preschool children with obesity who lived in Luoyang and underwent physical examination in the First Affiliated Hospital of Henan University of Science and Technology from February 2018 to December 2021 were collected for investigation.The epidemiological characteristics were analyzed.According to onset of T2DM,they were divided into T2DM group(52 cases)and non-T2DM group(148 cases).The influencing factors of occurrence of T2DM in preschool children in Luoyang were analyzed by Logistic regression analysis.Results Among the 200 preschool children with obesity,52 cases had T2DM,with case rate of 26.00%(52/200).Results of epidemiological investigation showed that the main onset age of T2DM was 6 to 7 years(90.38%,47/52),and the incidence of T2DM was higher in boys(73.08%,38/52).The proportion of preschool children with obesity degree≥40% was 55.77%(29/52);the proportion of T2DM preschool children with spontaneous delivery(67.31%,35/52)was higher than proportion of T2DM preschool children with cesarean section(32.69%,17/52).The proportion of artificial feeding was relatively higher(51.92%,27/52).The prevalence of T2DM was higher in children with maternal gestational diabetes mellitus,with obesity complicated by acanthosis nigricans,and with obvious family history of T2DM.The onset of T2DM was related to children’s age,gender,obesity degree,maternal gestational diabetes mellitus,acanthosis nigricans and family history of T2DM(P<0.05).The levels of fasting blood glucose and glycated hemoglobin in the T2DM group were higher than those in the non-T2DM group(all P<0.05).Results of Logistic regression analysis showed that gender,obesity degree,acanthosis nigricans and family history of T2DM were all influencing factors of occurrence of T2DM in preschool children with obesity in Luoyang(P<0.05).Conclusions The detection r

关 键 词：肥胖 学龄前儿童 2型糖尿病 流行病学 危险因素 

分 类 号：R725.8[医药卫生—儿科] R181.3[医药卫生—临床医学]