5-氨基酮戊酸光动力疗法治疗VLS的疗效及对TGF-β1、p16表达水平的影响  

Efficacy of 5-aminoketovaleric acid photodynamic therapy in the treatment of VLS and its effect on the expression levels of TGF-β1 and p16

作　　者：范虹鹤 孙淑红 王晓伟 刘蕊 FAN Hong-he;SUN Shu-hong;WANG Xiao-wei;LIU Rui(Department of Gynaecology,Chengde Maternal and Child Health Hospital,Hebei Province,Chengde 067000,China)

机构地区：[1]河北省承德市妇幼保健院妇科,河北承德067000

出　　处：《河北医科大学学报》2023年第2期179-183,共5页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题(20200349)。

摘　　要：目的探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid,5-ALA-PDT)治疗外阴硬化性苔藓(vulvar lichen sclerosus,VLS)的疗效及对转化生长因子β1(transforming growth factor-β1,TGF-β1)、p16表达水平的影响。方法选取河北省承德市妇幼保健院妇科收治的VLS患者146例,根据随机数字表法分为2组,观察组73例接受5-ALA-PDT治疗,对照组73例接受卤米松乳膏治疗。比较2组患者临床疗效、Cattaneo评分、VLS组织中TGF-β1mRNA、p16 mRNA表达和复发率。结果观察组总有效率高于对照组(P<0.05)。治疗后观察组瘙痒程度、皮肤弹性、皮肤颜色、病变范围评分和VLS组织中TGF-β1 mRNA表达低于对照组,p16 mRNA表达高于对照组(P<0.05)。随访6个月,观察组复发率低于对照组(P<0.05)。2组患者治疗过程中均未出现严重不良反应。结论5-ALA-PDT治疗VLS的疗效显著,能有效改善自觉和客观症状,降低VLS组织中TGF-β1 mRNA、p16 mRNA表达和复发率。Objective To investigate the efficacy of 5-aminoketovaleric acid photodynamic therapy(5-ALA-PDT)in the treatment of vulvar lichen sclerosus(VLS)and its effect on the expression levels of transforming growth factor-β1(TGF-β1)and p16.Methods A total of 146 patients with VLS admitted to the Department of Gynecology,Chengde Maternal and Child Health Hospital in Hebei Province were selected and divided into two groups according to the random number table method:73 cases in the observation group received 5-ALA-PDT and 73 cases in the control group received Halometasone cream.Clinical efficacy,Cattaneo scores,TGF-β1 mRNA and p16 mRNA expression in VLS tissues and recurrence rates between two groups were compared.Results Compared with the control group,the observation group had a higher total effective rate(P<0.05).Compared with the control group after treatment,pruritus,skin elasticity,skin colour,lesion extent score,TGF-β1 mRNA expression in VLS tissue was lower and p16 mRNA expression was higher in the observation group(P<0.05).At 6-month follow-up,the recurrence rate was lower in the observation group than in the control group(P<0.05).No serious adverse reactions were observed in either group.Conclusion 5-ALA-PDT is effective in the treatment of VLS,which can improve both subjective and objective symptoms,and reduce TGF-β1 mRNA,p16 mRNA expression and recurrence rate in VLS tissues.

关 键 词：外阴硬化性苔藓 5-氨基酮戊酸光动力疗法 转化生长因子-Β 

分 类 号：R711.72[医药卫生—妇产科学]