2型糖尿病患者血清甘丙肽及瘦素与冠状动脉粥样硬化性心脏病的相关性研究  

Correlation between serum Galanin, Leptin and coronary heart disease in patients with type 2 diabetes mellitus

作　　者：李敏[1] 李辉[2] 刘艳 张然然 张恒艳 杨青青[1] 孙卫华[1] 胡小磊[1] LI Min;LI Hui;LIU Yan(Department of Endocrinology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)

机构地区：[1]蚌埠医学院第一附属医院内分泌科,233000 [2]蚌埠医学院第一附属医院心血管内科 [3]江南大学附属医院超声医学科

出　　处：《中国糖尿病杂志》2022年第12期887-891,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81770803);安徽省高等学校自然科学研究重大项目(KJ2020ZD53);蚌埠医学院自然科学重点项目(2020byzd072);蚌埠医学院研究生科研创新计划项目(Byycx20075)。

摘　　要：目的 探讨T2DM患者血清甘丙肽(Galanin)、瘦素(Leptin)与冠状动脉粥样硬化性心脏病(CHD)的相关性。方法 选取2017年2月至2021年8月于我院心血管内科治疗的接受冠状动脉造影术(CAG)检查的患者366例,分为单纯T2DM组(n=88)、单纯CHD组(n=156)及T2DM合并CHD组(T2DM+CHD,n=122)。T2DM+CHD组分为轻度冠脉狭窄亚组43例、中度冠脉狭窄亚组35例和重度冠脉狭窄亚组44例。同期选取本院体检健康者74名为正常对照(NC)组。比较各组临床生化指标。结果 T2DM+CHD组血清Galanin、Leptin高于T2DM组(P<0.05)。重度冠脉狭窄亚组Galanin高于轻度冠脉狭窄、中度冠脉狭窄亚组(P<0.05)。Pearson相关分析显示,血清Galanin与Leptin、Gensini评分呈正相关(P<0.01)。Logistic回归分析显示,Galanin、Leptin及IL-6是T2DM合并CHD的影响因素。受试者工作特征曲线分析显示,Galanin联合Leptin评估CHD的敏感度和特异度为69.4%、76.5%。结论 高水平Galanin及Leptin是T2DM合并CHD的危险因素,二者联合可预测CHD。Objective To investigate correlation between serum Galanin,Leptin and coronary heart disease(CHD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 366 patients who underwent coronary angiography(CAG)in the Department of Cardiology of our hospital were enrolled in this study from February 2017 to August 2021. All the patients were divided into simple T2DM group(n=88),simple CHD group(n=156),and T2DM combined with CHD group(T2DM+CHD,n=122).The T2DM+CHD group was further divided into three subgroups:mild coronary stenosis(n=43),moderate coronary stenosis(n=35),and severe coronary stenosis(n=44). Meanwhile,74 healthy people were selected as normal control(NC)group from our hospital. The clinical biochemical indexes were compared among the three groups.Results The levels of serum Galanin and Leptin were higher in T2DM+CHD group than in T2DM group(P<0. 05). Galanin was higher in severe coronary stenosis subgroup than in mild and moderate coronary stenosis subgroup(P<0. 05). Pearson correlation analysis showed that serum Galanin was positively correlated with Leptin and Gensini scores(P<0. 01). Logistic regression analysis showed that Galanin,Leptin and IL-6 were risk factors for T2DM with CHD. The Receiver Operating Characteristic curve showed that the sensitivity and specificity of Galanin combined with leptin were 69. 4% and 76. 5% respectively.Conclusion High levels of serum Galanin and Leptin are risk factors for T2DM combined with CHD. Galanin combined with Leptin can be used as a predictor of T2DM combined with CHD.

关 键 词：糖尿病 2型 甘丙肽 瘦素 冠状动脉粥样硬化性心脏病 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]