脓毒症患者维生素C治疗的研究进展  

Research progress in the treatment of sepsis with vitamin C

作　　者：李珊 赵鹤龄[2] 申丽旻[2] Li Shan;Zhao Heling;Shen Limin(Graduate School of North China University of Science and Technology,Tangshan 063000,China;Department of Intensive Care Unit,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]华北理工大学研究生院,唐山063000 [2]河北省人民医院重症医学科,石家庄050051

出　　处：《中国医师杂志》2023年第1期148-152,共5页Journal of Chinese Physician

基　　金：河北省科技计划项目(152777146)。

摘　　要：脓毒症是感染引起的宿主反应失调,其中氧化应激参与器官损伤的发生机制。创伤和感染导致的维生素C缺乏在危重患者中十分常见。作为一种高效的抗氧化剂,维生素C具有缓解氧化应激、减轻炎症反应、保护内皮细胞功能、减少血小板活化等作用。但目前尚无确切的临床研究证实脓毒症患者通过补充维生素C可获得明显受益。为进一步探讨脓毒症患者应用维生素C的临床价值,本文就脓毒症的病理生理学特点、维生素C的生理功能及缺乏症表现、维生素C的基础及临床试验研究等方面展开论述。Sepsis is a host reaction disorder caused by infection,in which oxidative stress is involved in the mechanism of organ damage.Vitamin C deficiency caused by trauma and infection is very common in critically ill patients.As a highly effective antioxidant,vitamin C can alleviate oxidative stress,reduce the inflammatory response,protect endothelial cell function,and reduce platelet activation.However,no definite clinical study confirms that patients with sepsis can benefit significantly from vitamin C supplementation.In order to further explore the clinical value of vitamin C in patients with sepsis,this paper discusses the pathophysiology of sepsis,the physiological function and deficiency of vitamin C,the basic research and clinical trials of vitamin C.

关 键 词：脓毒症 维生素C 炎症 氧化应激 

分 类 号：R459.7[医药卫生—急诊医学]