围绝经期女性发生阻塞性睡眠呼吸暂停低通气综合征的临床特征和相关危险因素分析  

Analysis of clinical characteristics and related risk factors of OSAHS in perimenopausal period women

作　　者：丁凌[1] 冷报浪[1] 董洪英[1] 冯霞 DING Ling;LENG Bao-lang;DONG Hong-ying;FENG Xia(Department of Respiratory Medicine,Hangzhou Third People's Hospital,Hangzhou,Zhejiang 310009,China)

机构地区：[1]杭州市第三人民医院呼吸内科,浙江杭州310009

出　　处：《中国妇幼保健》2023年第1期156-159,共4页Maternal and Child Health Care of China

基　　金：浙江省中医药科技计划(2019ZB103)。

摘　　要：目的分析围绝经期女性发生阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床特征和相关危险因素,旨在指导临床防治。方法选取2017年6月—2019年6月杭州市第三人民医院收治的发生OSAHS的围绝经期患者65例为研究对象,设为发病组,另选取同期该院收治的存在睡眠障碍但排除OSAHS的患者15例设为对照组。所有患者均通过调查问卷进行资料的采集与评估,包括年龄、吸烟史、饮酒史、腹围、体质指数、高血压疾病、糖尿病及实验室指标,对患者的临床特征和危险因素进行分析。结果单因素分析结果显示,两组患者年龄[发病组(46.98±8.23)岁,对照组(44.74±7.35)岁]、腹围[发病组(98.43±6.25)cm,对照组(88.43±5.36)cm]、体质指数[发病组(28.35±3.36)kg/m2,对照组(25.43±3.56)kg/m2]、合并高血压疾病(发病组32.31%,对照组13.33%)及糖尿病(发病组30.77%,对照组13.33%)等因素比较,差异均有统计学意义(t/χ^(2)=3.995、5.489、4.642、5.645及5.417,均P<0.05)。多因素logistic回归分析结果显示,年龄≥45岁、腹围≥98 cm、合并高血压及合并糖尿病为围绝经期女性发生OSAHS的独立危险因素(均P<0.05,OR>1)。结论围绝经期女性具有较高的OSAHS发病率,其严重程度可随时间延长而逐渐加重;年龄、腹围、合并高血压疾病及合并糖尿病为围绝经期女性发生OSAHS的独立危险因素。随着女性年龄增长和肥胖程度增加,特别是合并高血压疾病、糖尿病等症状,需及时进行OSAHS筛查,争取做到早期诊断、针对纠治,积极采取减重等干预措施,有效控制OSAHS的发生与进展。Objective To analyze the clinical features and related risk factors of obstructive sleep apnea-hypopnea syndrome(OSAHS)in perimenopausal period women,in order to guide clinical prevention and treatment.Methods From June 2017 to June 2019,65 climacteric female patients with OSAHS who were admitted to Hangzhou Third People's Hospital were selected as the research object,and they were set as the incidence group,and the patients with sleep disorders who were admitted to the hospital during the same period but excluded OSAHS were selected,15 patients were set as the control group.All patients were collected and evaluated by questionnaire,including age,smoking history,drinking history,abdominal circumference,body mass index,hypertensive disease,diabetes and laboratory indicators,and the clinical characteristics and risk factors of the patients were analyzed.Results The results of univariate analysis showed that the age of the two groups[incidence group(46.98±8.23)years,control group(44.74±7.35)years],abdominal circumference[incidence group(98.43±6.25)cm,control group(88.43±5.36)cm],body mass index[incidence group(28.35±3.36)kg/m2,control group(25.43±3.56)kg/m2],combined with hypertension(32.31%in the incidence group,13.33%in the control group)and diabetes(30.77%in the incidence group,13.33%in the control group),the differences were statistically significant(t/χ^(2)=3.995,5.489,4.642,5.645 and 5.417,P<0.05).Multivariate logistic regression analysis showed that age≥45 years old,abdominal circumference≥98 cm,hypertension and diabetes were the independent risk factors for OSAHS in perimenopausal period women(P<0.05,OR>1).Conclusion Perimenopausal period women have a higher incidence of OSAHS,and its severity can gradually increase with time.Age,abdominal circumference,combined with hypertension and diabetes are independent risk factors for OSAHS in perimenopausal period women.With the increase in age and obesity of women,especially those with symptoms such as hypertension and diabetes,OSAHS screening needs to be

关 键 词：围绝经期女性 阻塞性睡眠呼吸暂停低通气综合征 高血压 糖尿病 临床特征 影响因素 

分 类 号：R318.13[医药卫生—生物医学工程]