用于皮肤伤口愈合的仿生天然产物的医用粘合剂研究进展  

Progress in medical adhesives for biomimetic natural products for skin wound healing

作　　者：陈玉琴 王晓萍 张曦木 CHEN Yu-qin;WANG Xiao-ping;ZHANG Xi-mu(Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing City,401120,China;Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing City,401120,China;Prevention of stomatology,Stomatological Hospital of Chongqing Medical University,Chongqing City,401120,China;Periodontology,Stomatological Hospital of Chongqing Medical University,Chongqing City,401120,China)

机构地区：[1]口腔疾病与生物医学重庆市重点实验室,重庆401120 [2]重庆市高校市级口腔生物医学工程重点实验室,重庆401120 [3]重庆医科大学附属口腔医院预防口腔科,重庆401120 [4]重庆医科大学附属口腔医院牙周科,重庆401120

出　　处：《中国医疗美容》2023年第1期49-52,共4页China Medical Cosmetology

基　　金：国家自然科学基金(32070826)。

摘　　要：组织粘合剂或伤口敷料可以保护伤口表面并提供有利于伤口愈合的环境。组织粘合剂作为封闭创口或止血的缝合线/钉的替代品,近年来在创伤修复领域受到越来越多的关注。但目前大多数商用组织粘合剂存在粘合强度不足,生物相容性欠佳,功能单一等问题。幸运的是,自然界存在许多天然粘性产物,它们为医用粘合剂的开发提供了新的思路。本文将就天然粘性产物粘合机制及受其影响开发的相关仿生粘合材料进行综述。Tissue adhesives or wound dressings can protect the wound surface and provide an environment favorable for wound healing.Tissue adhesives,as alternatives to sutures/nails that seal the wound or stop bleeding,have received increasing attention in the field of trauma repair in recent years.However,most commercial tissue adhesives have problems such as insufficient adhesion strength,poor biocompatibility and single function.Fortunately,many natural adhesive products exist in nature,which provides new ideas for the development of medical adhesives.This paper provides an overview of the natural sticky products and their adhesive mechanisms secreted by mussels,such as mussels,bunker worms,spider webs,ivy and others,and briefly describes the relevant biomimetic adhesive materials developed by their influence.

关 键 词：皮肤 伤口愈合 组织粘合剂 天然粘合剂 仿生材料 

分 类 号：R318.08[医药卫生—生物医学工程]