细菌性肺炎患儿肠道微生态及其与血FOXP3、G-CSF水平的关系  

Intestinal microecology and its relationship with serum FOXP3 and G-CSF levels in children with bacterial pneumonia

作　　者：党赫铭 高萃[1] 冯孝强[1] 姜华 DANG Heming;GAO Cui;FENG Xiaoqiang;JIANG Hua(Department of Pediatrics,Affiliated Hospital of Yan'an University,Yan'an 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院儿科,陕西延安716000

出　　处：《中南医学科学杂志》2023年第1期130-132,共3页Medical Science Journal of Central South China

基　　金：延安市科技惠民计划项目(2018-HM-08-01)。

摘　　要：目的 研究细菌性肺炎患儿肠道微生态及其与血清转录因子叉头蛋白(FOXP3)、粒细胞-巨噬细胞集落刺激因子(G-CSF)水平的关系。方法 选择细菌性肺炎患儿120例为肺炎组,其中轻度组55例,重度组65例,另选取同期健康体检患儿120例为对照组。比较各组肠道微生物、血清FOXP3、G-CSF水平,分析肠道微生物与FOXP3、G-CSF水平的相关性。结果 肺炎组乳杆菌、双歧杆菌、肠球菌及真杆菌水平低于对照组;重度组乳杆菌、双歧杆菌、肠球菌及真杆菌低于轻度组;肺炎组FOXP3、G-CSF高于对照组,重度组FOXP3、G-CSF高于轻度组(P<0.05)。双歧杆菌、肠球菌、乳杆菌及真杆菌与FOXP3、G-CSF呈负相关(P<0.05)。结论 细菌性肺炎患儿肠道微生态与肺炎病情程度有关,且与血清FOXP3、G-CSF呈负相关。Aim To study the relationship of intestinal microecology with serum forkheadbox protein 3(FOXP3) and granulocyte-macrophage colony-stimulating factor(G-CSF) levels in children with bacterial pneumonia. Methods120 children with bacterial pneumonia were selected as the pneumonia group, including 55 cases in the mild group and 65 cases in the severe group. Another 120 healthy children in the same period were selected as the control group. The intestinal microorganisms and levels of serum FOXP3 and G-CSF in each group were compared, and the correlation of intestinal microorganisms with FOXP3 and G-CSF levels was analyzed. Results Lactobacillus, Bifidobacterium, Enterococcus and Eubacterium in pneumonia group were lower than those in control group;Lactobacillus, Bifidobacteria, Enterococcus and Eubacterium in severe group were lower than those in mild group;The levels of FOXP3 and G-CSF in the pneumonia group were higher than those in the control group, and the levels of FOXP3 and G-CSF in the severe group were higher than those in the mild group(P<0.05). Bifidobacteria, Enterococcus, Lactobacillus and Eubacterium were negatively correlated with FOXP3 and G-CSF(P<0.05). Conclusion The intestinal microecology in children with bacterial pneumonia is related to the severity of pneumonia, and negatively correlated with serum FOXP3 and G-CSF.

关 键 词：细菌性肺炎 肠道菌群 免疫功能 FOXP3 G-CSF 

分 类 号：R725.6[医药卫生—儿科]