胶原的百年研究历程回顾与展望  

Retrospect of 100-year research of collagen and prospect

作　　者：张贵锋[1] 高建萍[1] 徐丽明[2] 罗希 赵凌云 ZHANG Guifeng;GAO Jianping;XU Liming;LUO Xi;ZHAO Lingyun(Institute of Process Engineering Chinese Academy of Sciences,Beijing 100190 China;National Institutes for Food and Drug Control,Beijing 100050 China;School of Materials Science&Engineering Tsinghua University,Beijing 100084 China)

机构地区：[1]中国科学院过程工程研究所,北京100190 [2]中国食品药品检定研究院,北京100050 [3]清华大学材料学院,北京100084

出　　处：《生物学杂志》2023年第1期1-8,共8页Journal of Biology

基　　金：国家重点研发计划项目(2021YFC2400804);生化工程国家重点实验室开放基金项目(2021KF-04)。

摘　　要：胶原作为细胞外基质的主要成分,是脊椎动物体内含量最丰富的蛋白。胶原研究历程与人们对生命本质的认识过程密不可分,从纤维学说到细胞学说确立经历了数百年的历程。近百年来,胶原的应用从制革和黏合剂等,逐渐拓展至食品、药品、化妆品、生物材料,近年来拓展至组织工程、再生医学及干细胞定向转化等。结合已有的文献报道及相关研究经验,针对胶原的研究历程、应用范围以及相关技术在胶原研究中的应用、取得的阶段性进步或成果等进行梳理。以期为胶原领域的研究人员提供胶原研究的最新动向,使其充分理解技术进步与科学研究之间的关系,同时有助于促进不同学科领域的交叉与融合。Collagen, a major component of the extracellular matrix, is the most abundant protein in vertebrates. The history of collagen research is inextricably linked to the process of understanding the nature of life, which has taken centuries to establish from the fiber theory to cell theory. Over the past hundred years, the application of collagen has gradually expanded from leather preparation and adhesives to food, pharmaceuticals, cosmetics, biomaterials. In recent years, it has expanded to tissue engineering, regenerative medicine and stem cell targeted transformation. The history of collagen research, the scope of application, the application of related technologies, and the milestones or results achieved were reviewed in the light of the available literature reports and related research experiences. The aim was to provide researchers in the field of collagen with the latest trends in collagen research, so that they can fully understand the relationship between technological advances and scientific research, while helping to promote the intersection and integration of different research fields.

关 键 词：胶原 细胞外基质 胶原-细胞相互作用 组织工程 再生医学 

分 类 号：Q512[生物学—生物化学] Q789[化学工程] TQ936