β-受体阻滞剂通过线粒体氧化应激途径减轻老年重度心力衰竭患者心肌缺血再灌注损伤  

β-blockers Reduce Myocardial Ischemia-reperfusion Injury in Elderly Patients with Severe Heart Failure Through Mitochondrial Oxidative Stress Pathway

作　　者：郭亭亭 GUO Ting-ting(Shangqiu First People's Hospital,Shangqiu 476100,Henan Province,China)

机构地区：[1]商丘市第一人民医院,河南商丘476100

出　　处：《罕少疾病杂志》2023年第2期33-35,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究β-受体阻滞剂是否会对老年重度心力衰竭患者的临床效果和生存质量造成影响。方法选择符合纳入要求的老年重度心力衰竭患者60例随机分为观察组和对照组2组,每组各30例患者,对照组和观察组分别通过常规药物利尿剂和洋地黄治疗、β-受体阻滞剂完成相应的治疗。评估治疗效果、生存质量和治疗期间药物带来的不良反应。在治疗后,通过超声心动图检测患者左室射血分数(LVEF)、左室舒张末期直径(LVEDd)、左室收缩末期直径(LVESd);利用实时PCR检测外周血过氧化物酶体增殖激活受体γ共激活因子1-α(PGC1α)、超氧化物歧化酶(SOD2)和柠檬酸合成酶(Cs)m RNA的表达量。结果观察组和对照组治疗总有效率分别为96.67%和80.00%,并且在治疗2周后观察组的生存质量显著优于对照组(P<0.05)。综合分析两组不良反应的发生率,差异则无统计学差异(P>0.05)。观察组LVEDd和LVESd明显低于对照组(P<0.05),LVEF显著高于对照(P<0.05);与对照组相比,观察组PGC1-a、SOD2和Cs基因的表达水平显著降低(P<0.05)。结论β-受体阻滞剂可减轻缺血再灌注所致线粒体的损伤,从而提高患者的治疗效果和生活质量。Objective To investigate whetherβ-blockers affect clinical outcome and quality of life in elderly patients with severe heart failure.Methods Sixty elderly patients with severe heart failure who met the inclusion requirements were randomly divided into observation group and control group,with 30 patients in each group.The control group and observation group were treated with conventional drugs diuretics,digitalis andβ-blockers,respectively.Evaluation of treatment efficacy,quality of life and adverse drug reactions during treatment.After treatment,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDd)and left ventricular end systolic diameter(LVESd)were measured by echocardiography.Real-time PCR was used to detect the m RNA expression levels of peroxisome-proliferation-activated receptorγcoactivator 1-α(PGC1α),superoxide dismutase(SOD2)and citrate synthase(Cs)in peripheral blood.Results The total effective rate of the observation group and the control group was 96.67%and 80.00%,respectively,and the quality of life of the observation group was significantly better than that of the control group after 2 weeks of treatment(P<0.05).Comprehensive analysis of the incidence of adverse reactions between the two groups showed no statistical difference(P>0.05).LVEDd and LVESd in observation group were significantly lower than those in control group(P<0.05),and LVEF was significantly higher than that in control group(P<0.05).Compared with the control group,the expression levels of PGC1-A,SOD2 and Cs genes in observation group were significantly decreased(P<0.05).Conclusionβ-receptor blockers can reduce the mitochondrial damage caused by ischemia-reperfusion,thus improving the therapeutic effect and quality of life of patients.

关 键 词：Β-受体阻滞剂 老年重度心力衰竭 线粒体氧化应激 心肌缺血再灌注损伤 生存质量 

分 类 号：R541.62[医药卫生—心血管疾病]