基于丝蛋白纳米颗粒负载抗癌药物递送系统的研究进展  

Research development of the anti-cancer drug delivery system based on silk fibroin nanoparticles

作　　者：吴建兵 李靖雯 周欣楠 孙银银 王永峰[2] WU Jianbing;LI Jingwen;ZHOU Xinnan;SUN Yinyin;WANG Yongfeng(School of Textile Clothing and Design,Changshu Institute of Technology,Suzhou 215500,China;International Laboratory,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,China)

机构地区：[1]常熟理工学院纺织服装与设计学院,江苏苏州215500 [2]中国科学院苏州纳米技术与纳米仿生所国际实验室,江苏苏州215123

出　　处：《丝绸》2023年第2期24-34,共11页Journal of Silk

基　　金：国家自然科学青年基金项目(51903019);江苏省高等学校自然科学面上基金项目(17KJB540001,19KJB430006);常熟理工学院大学生创新创业计划项目(XJDC2020110)。

摘　　要：针对抗癌药物存在血液循环清除快、易脱靶、生物利用度低等问题,本文对抗癌药物递送系统中丝蛋白纳米颗粒的材料选择,方法原理分类及优缺点、理化性能对抗癌药物递送的影响及其在被主动靶向递送中的具体研究进展进行全面综述,并重点比较了丝蛋白纳米颗粒的制备方法及其理化性能对抗癌药物负载和递送的影响。综合分析表明,丝蛋白纳米颗粒的研究应着重从方法创新、提升其理化性能及精准靶向与延长疗效等多方面协同入手,充分发挥其在抗癌药物递送系统中的各种优势,为促进癌症病人的高效治疗提供更多选择机会。Cancer has become a serious threat to human health,bringing a heavy burden to families and society.Terminal cancer patients can only rely on anticancer drugs to prolong life,while the drgus have high toxicity but no cell selectivity.In addition,as for anticancer drugs,there exist problems such as fast blood circulation clearance,easiness to miss the target and low bioavailability.Anticancer drugs are embedded in inorganic or organic polymer carriers,and enter the body through different drug delivery routes,and then,the drugs are delivered to the targeted sites through blood circulation.How to maintain the drug therapeutic concentration for a long time and give full play to the drug efficacy is a hotspot that researchers at home and abroad generally pay attention to.How to reduce and avoid the uptake of polymer carriers by liver RES remains a major challenge.Using polymer nanoparticles for drug delivery is one of the effective ways to solve this problem,but there are still some limitations.Adding organic solvents,initiators and other chemical substances in the preparation process of nanoparticles may cause safety hazards.In the process of high temperature sterilization,some synthetic polymers are degraded and can not stabilize and protect anticancer drugs.The acidic products degraded in vivo will acylate with macromolecular anticancer drugs.Compared with synthetic polymers,silk fibroin exhibits outstanding advantages and strong plasticity and can be flexibly and efficiently loaded with anticancer drugs by physical or chemical methods,stabilize the activity of anticancer drugs,and realize the controlled and precise release of anticancer drugs.Moreover,silk fibroin can be enzymically degraded in the natural environment,and the degradation products are harmless to human body and environment.Silk fibroin nanoparticles have made a breakthrough in the loading and delivery of anticancer drugs.In this article,we summarize the advantages of silk fibroin nanoparticles in anticancer drug delivery system.Specifically,the uniq

关 键 词：抗癌药物 纳米颗粒 丝蛋白 递送系统 被动靶向 主动靶向 

分 类 号：TS101.4[轻工技术与工程—纺织工程]