生物活性丝素蛋白敷料在创面修复中的研究进展  

Research progress on bioactive silk protein dressings in wound repair

作　　者：管彤 张锋 GUAN Tong;ZHANG Feng(College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China;National Engineering Laboratory for Modern Silk,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215021 [2]苏州大学现代丝绸国家工程实验室,江苏苏州215021

出　　处：《丝绸》2023年第2期35-41,共7页Journal of Silk

摘　　要：创面敷料可以加速伤口愈合、缓解病人疼痛、避免进一步的组织炎症、减少疤痕组织的形成,临床上通常选用适当的伤口敷料营造有利于伤口组织修复的微环境。丝素蛋白作为一种力学性能优异、生物相容性好、易塑形和生物可吸收的天然生物材料,在创面修复中的应用备受关注。本文基于丝素蛋白应用于创面修复的生物学特性介绍,重点阐述了通过结构性能设计、药物与因子负载、干细胞复合形成的生物活性丝素蛋白敷料的研究进展,并对丝素蛋白敷料今后的研究方向进行了展望,为活性丝素蛋白敷料的进一步开发与应用提供参考。As the first line of defense to protect the human body,skin is susceptible to varying degrees of injury from external forces,heat,disease,and chemical corrosion.Wound dressings constructed based on tissue engineering principles can effectively improve clinical tissue repair,accelerate the wound repair process,relieve patient pain,and reduce scar formation.Silk fibroin,a natural polymer with the advantages of abundant sources,excellent mechanical properties,degradability,and good biocompatibility,is especially favored by researchers in the field of wound repair.In recent years,based on the extensive research on the application of silk fibroin in skin wound repair,the biological properties of silk fibroin for wound repair have been gradually elucidated and become an important reference to guide the design and construction of wound repair materials.Through the design of structure and properties,drug and biological factor loading,and stem cell compounding of silk fibroin dressings,the functions of silk fibroin dressings to prevent wound infection,promote wound healing,and reduce scar regeneration have been realized.Wound healing is a continuous and slow process that is divided into four main stages:hemostasis,inflammation,proliferation and remodeling.Silk fibroin is involved in almost every step of wound healing.Silk fibroin can achieve hemostasis by dissolution or adhesion to the wound and cause a mild inflammatory response during the initial phase of implantation,which facilitates the destruction of pathogens present at the site of injury and accelerates wound repair.Silk fibroin can also promote the expression of fibroblast fibronectin and vascular endothelial growth factor,activate NF-κB signaling pathway,promote vascular neovascularization,develop granulation tissue,and epithelization.With the further development and research on silk fibroin,the functional properties of silk fibroin materials related to wound repair have been gradually elucidated,which has become an important clue for the design and constructio

关 键 词：丝素蛋白 生物活性 创伤敷料 创面修复 组织工程 皮肤 

分 类 号：TS102.33[轻工技术与工程—纺织工程]