气相色谱-质谱法测定化妆品中斑蝥素和氮芥  

Determination of cantharidin and nitrogen mustard in cosmetic by gas chromatography-mass spectrometry

作　　者：吕琼芳 彭敏[1] 梁惠明[1] 黄少宏[1] LYU Qiongfang;PENG Min;LIANG Huiming;HUANG Shaohong(Jiangmen Institute for Drug Control,Jiangmen 529000,China)

机构地区：[1]江门市药品检验所,广东江门529000

出　　处：《化学分析计量》2023年第1期45-49,共5页Chemical Analysis And Meterage

摘　　要：建立气相色谱-质谱法同时测定化妆品中斑蝥素和氮芥的含量。以色谱纯三氯甲烷为溶剂提取化妆品中的斑蝥素和氮芥两种组分,用气相色谱-质谱(GC-MS)法进行分析,各目标组分均能有效分离,且色谱峰形良好。斑蝥素和氮芥在质量浓度0.5~10μg/mL范围内线性良好,线性相关系数均为0.998,平均加标回收率分别为102.6%和115.7%。测定结果的相对标准偏差分别为1.2%和2.1%(n=6)。该方法适用于化妆品中斑蝥素和氮芥两种禁用组分同时测定。An optimized method was established for the simultaneous determination of cantharidin and nitrogen mustard in cosmetics by gas chromatography-mass spectrometry(GC-MS).Cantharidin and nitrogen mustard were extracted with chromatographic pure chloroform and determined by GC-MS.All target components can be separated effectively,and the chromatographic peak shape was good.Cantharidin and nitrogen mustard had good linearity in the range of 0.5-10μg/mL with the corelation coefficients of 0.998,the average recoveries were 102.6%and 115.7%,respectively.The relative standard deviations of the results were 1.2%and 2.1%(n=6).The method is suitable for the simultaneous determination of cantharidin and nitrogen mustard in cosmetics.

关 键 词：化妆品 斑蝥素 氮芥 气相色谱-串联质谱法 禁用组分 

分 类 号：O657.7[理学—分析化学]