PI3K/Akt信号通路与畜禽繁殖关系的研究进展  

Research Progress on the Relationship between PI3K/Akt Signaling Pathway and Livestock and Poultry Reproduction

作　　者：张蕾[1] 章敬旗[1] 张泰 王健[1] ZHANG Lei;ZHANG Jingqi;ZHANG Tai;WANG Jian(Jiangsu Agri-animal Husbandry Vocational College,Taizhou,Jiangsu 225300,China)

机构地区：[1]江苏农牧科技职业学院,江苏泰州225300

出　　处：《家畜生态学报》2023年第1期88-92,共5页Journal of Domestic Animal Ecology

基　　金：国家自然科学基金青年基金项目(No.32002157);江苏省高校自然科学研究项目(No.20KJD230001);江苏农牧科技职业学院院级课题(No.NSFZP202101)。

摘　　要：畜禽繁殖力是提高畜牧业生产力的关键性因素,生殖细胞是畜禽繁殖力的主要载体。生殖细胞的发生、发育和成熟受到机体内信号通路的调控。其中,PI3K/Akt信号通路在细胞增殖、分化和凋亡等生物学行为中发挥重要的调控作用。近来的研究表明,该通路的激活对畜禽精子发生和卵泡发育等过程有重要的生物学作用。本综述就PI3K/Akt信号通路与畜禽繁殖相关调控作用进行概述,以期从分子机制上为提高畜禽繁殖力提供新的视角。The reproductive capacity of livestock and poultry is the key factor to improve the productivity of animal husbandry,of which the germ cell is the main carrier.The genesis,development and maturation of germ cells are regulated by signaling pathways.Among them,PI3K/Akt signaling pathway plays an important role in cell proliferation,differentiation and apoptosis.Recent studies showed that the activation of PI3K/Akt signaling pathway plays an important role in the process of spermatogenesis and follicular development.This review summarizes the regulatory role of PI3K/Akt signaling pathway in livestock and poultry reproduction,in order to provide a new perspective for improving livestock and poultry reproductive capacity from the molecular mechanism.

关 键 词：PI3K/AKT 繁殖力 精子发生 卵泡发育 

分 类 号：S814[农业科学—畜牧学]